How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution

EA Groisman, A Duprey, J Choi - Microbiology and Molecular …, 2021 - Am Soc Microbiol
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …

Salmonellae interplay with host cells

A Haraga, MB Ohlson, SI Miller - Nature Reviews Microbiology, 2008 - nature.com
Salmonellae are important causes of enteric diseases in all vertebrates. Characterization of
the molecular mechanisms that underpin the interactions of salmonellae with their animal …

Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors

R Figueira, DW Holden - Microbiology, 2012 - microbiologyresearch.org
Salmonella enterica serovars cause severe disease in humans, such as gastroenteritis and
typhoid fever. The bacteria are able to invade and replicate within host cells, including …

Typhoidal Salmonella: Distinctive virulence factors and pathogenesis

R Johnson, E Mylona, G Frankel - Cellular microbiology, 2018 - Wiley Online Library
Although nontyphoidal Salmonella (NTS; including Salmonella Typhimurium) mainly cause
gastroenteritis, typhoidal serovars (Salmonella Typhi and Salmonella Paratyphi A) cause …

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

S Li, L Zhang, Q Yao, L Li, N Dong, J Rong, W Gao… - Nature, 2013 - nature.com
The tumour necrosis factor (TNF) family is crucial for immune homeostasis, cell death and
inflammation. These cytokines are recognized by members of the TNF receptor (TNFR) …

Salmonella bongori Provides Insights into the Evolution of the Salmonellae

M Fookes, GN Schroeder, GC Langridge… - PLoS …, 2011 - journals.plos.org
The genus Salmonella contains two species, S. bongori and S. enterica. Compared to the
well-studied S. enterica there is a marked lack of information regarding the genetic makeup …

Genome-Wide Screen for Salmonella Genes Required for Long-Term Systemic Infection of the Mouse

TD Lawley, K Chan, LJ Thompson, CC Kim… - PLoS …, 2006 - journals.plos.org
A microarray-based negative selection screen was performed to identify Salmonella enterica
serovar Typhimurium (serovar Typhimurium) genes that contribute to long-term systemic …

Regulated necrosis, a proinflammatory cell death, potentially counteracts pathogenic infections

G Zhang, J Wang, Z Zhao, T **n, X Fan, Q Shen… - Cell Death & …, 2022 - nature.com
Since the discovery of cell apoptosis, other gene-regulated cell deaths are gradually
appreciated, including pyroptosis, ferroptosis, and necroptosis. Necroptosis is, so far, one of …

SseL, a Salmonella deubiquitinase required for macrophage killing and virulence

A Rytkönen, J Poh, J Garmendia… - Proceedings of the …, 2007 - National Acad Sciences
Expression of the Salmonella enterica serovar Typhimurium pathogenicity island 2 (SPI-2)
type III secretion system is controlled by the two-component regulatory system SsrA-SsrB …

The PhoP/PhoQ system controls the intramacrophage type three secretion system of Salmonella enterica

JJE Bijlsma, EA Groisman - Molecular microbiology, 2005 - Wiley Online Library
Spi/Ssa is a unique type three secretion system that functions exclusively when Salmonella
enterica is inside eukaryotic cells. Expression of the Spi/Ssa system and its secreted …