ABC transporters in cancer stem cells: beyond chemoresistance
The efficacy of chemotherapy is one of the main challenges in cancer treatment and one of
the major obstacles to overcome in achieving lasting remission and a definitive cure in …
the major obstacles to overcome in achieving lasting remission and a definitive cure in …
Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
The role of the ATP-binding cassette A1 (ABCA1) in human disease
Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …
ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates
The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
ABC transporters as mediators of drug resistance and contributors to cancer cell biology
JI Fletcher, RT Williams, MJ Henderson… - Drug Resistance …, 2016 - Elsevier
The extrusion of anticancer drugs by members of the ATP-binding cassette (ABC)
transporter family is one of the most widely recognized mechanisms of multidrug resistance …
transporter family is one of the most widely recognized mechanisms of multidrug resistance …
[HTML][HTML] The ABC subfamily A transporters: Multifaceted players with incipient potentialities in cancer
Overexpression of ATP-binding cassette (ABC) transporters is a cause of drug resistance in
a plethora of tumors. More recent evidence indicates additional contribution of these …
a plethora of tumors. More recent evidence indicates additional contribution of these …
[HTML][HTML] ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance
W Muriithi, LW Macharia, CP Heming… - Cancer biology & …, 2020 - ncbi.nlm.nih.gov
The ATP-binding cassette transporters (ABC transporters) have been intensely studied over
the past 50 years for their involvement in the multidrug resistance (MDR) phenotype …
the past 50 years for their involvement in the multidrug resistance (MDR) phenotype …
[HTML][HTML] New dawn for cancer cell death: emerging role of lipid metabolism
C Zhang, N Zhu, H Li, Y Gong, J Gu, Y Shi, D Liao… - Molecular …, 2022 - Elsevier
Background Resistance to cell death, a protective mechanism for removing damaged cells,
is a “Hallmark of Cancer” that is essential for cancer progression. Increasing attention to …
is a “Hallmark of Cancer” that is essential for cancer progression. Increasing attention to …
The role of eukaryotic and prokaryotic ABC transporter family in failure of chemotherapy
Over the years chemotherapy failure has been a vital research topic as researchers have
been striving to discover reasons behind it. The extensive studies carried out on …
been striving to discover reasons behind it. The extensive studies carried out on …
The role of ABC transporters in ovarian cancer progression and chemoresistance
Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …
course of the disease. A well-established cause of chemoresistance involves the family of …