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PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives
The protein kinases regulate cellular functions such as transcription, translation,
proliferation, growth and survival by the process of phosphorylation. Over activation of …
proliferation, growth and survival by the process of phosphorylation. Over activation of …
Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update
ABSTRACT Introduction Mesoporous silica nanoparticles (MSNs) are outstanding
nanoplatforms for drug delivery. Herein, the most recent advances to turn MSN-based …
nanoplatforms for drug delivery. Herein, the most recent advances to turn MSN-based …
RETRACTED: Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT …
J Zhou, Y Jiang, H Chen, Y Wu, L Zhang - Cell proliferation, 2020 - Wiley Online Library
Abstract Objectives Tanshinone I (Tan‐I) is one of the vital fatsoluble monomer components,
which extracted from Chinese medicinal herb Salvia miltiorrhiza Bunge. It has been shown …
which extracted from Chinese medicinal herb Salvia miltiorrhiza Bunge. It has been shown …
Concanavalin A as a promising lectin-based anti-cancer agent: The molecular mechanisms and therapeutic potential
Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-
neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much …
neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much …
[HTML][HTML] Lectins with potential for anti-cancer therapy
This article reviews lectins of animal and plant origin that induce apoptosis and autophagy of
cancer cells and hence possess the potential of being developed into anticancer drugs …
cancer cells and hence possess the potential of being developed into anticancer drugs …
Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives
Autophagy is an intracellular catabolic self-cannibalism that eliminates dysfunctional
cytoplasmic cargos by the fusion of cargo-containing autophagosomes with lysosomes to …
cytoplasmic cargos by the fusion of cargo-containing autophagosomes with lysosomes to …
Plant lectins in cancer therapeutics: Targeting apoptosis and autophagy-dependent cell death
Plant lectins are non-immunoglobin in nature and bind to the carbohydrate moiety of the
glycoconjugates without altering any of the recognized glycosyl ligands. Plant lectins have …
glycoconjugates without altering any of the recognized glycosyl ligands. Plant lectins have …
Plant‐derived lectins as potential cancer therapeutics and diagnostic tools
M Mazalovska, JC Kouokam - BioMed Research International, 2020 - Wiley Online Library
Cancer remains a global health challenge, with high morbidity and mortality, despite the
recent advances in diagnosis and treatment. Multiple compounds assessed as novel …
recent advances in diagnosis and treatment. Multiple compounds assessed as novel …
Research advances and prospects of legume lectins
R Katoch, A Tripathi - Journal of biosciences, 2021 - Springer
Lectins are widely distributed proteins having ability of binding selectively and reversibly
with carbohydrates moieties and glycoconjugates. Although lectins have been reported from …
with carbohydrates moieties and glycoconjugates. Although lectins have been reported from …
[PDF][PDF] Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity
Lipotoxicity induced by saturated fatty acids (SFAs) plays a central role in the pathogenesis
of nonalcoholic fatty liver disease (NAFLD); however, the exact mechanisms remain to be …
of nonalcoholic fatty liver disease (NAFLD); however, the exact mechanisms remain to be …