Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

Drug repurposing approach to fight COVID-19

TU Singh, S Parida, MC Lingaraju, M Kesavan… - Pharmacological …, 2020 - Springer
Currently, there are no treatment options available for the deadly contagious disease,
coronavirus disease 2019 (COVID-19). Drug repurposing is a process of identifying new …

Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment

S Boopathi, AB Poma, P Kolandaivel - Journal of Biomolecular …, 2021 - Taylor & Francis
In the past two decades, the world has faced several infectious disease outbreaks. Ebola,
Influenza A (H1N1), SARS, MERS, and Zika virus have had a massive global impact in terms …

Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach

SK Enmozhi, K Raja, I Sebastine… - Journal of biomolecular …, 2021 - Taylor & Francis
SARS-CoV-2 virus which caused the global pandemic the Coronavirus Disease-2019
(COVID-2019) has infected about 1,203,959 patients and brought forth death rate about …

An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study

S Das, S Sarmah, S Lyndem… - Journal of Biomolecular …, 2021 - Taylor & Francis
A new strain of a novel infectious disease affecting millions of people, caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently been declared as a …

Drug repurposing for coronavirus (COVID-19): in silico screening of known drugs against coronavirus 3CL hydrolase and protease enzymes

AD Elmezayen, A Al-Obaidi, AT Şahin… - Journal of Biomolecular …, 2021 - Taylor & Francis
Abstract In December 2019, COVID-19 epidemic was described in Wuhan, China, and the
infection has spread widely affecting hundreds of thousands. Herein, an effort was made to …

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective

AA Elfiky - Journal of Biomolecular Structure and Dynamics, 2021 - Taylor & Francis
New treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge
health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising …

Using X-ray images and deep learning for automated detection of coronavirus disease

K El Asnaoui, Y Chawki - Journal of Biomolecular Structure and …, 2021 - Taylor & Francis
Coronavirus is still the leading cause of death worldwide. There are a set number of COVID-
19 test units accessible in emergency clinics because of the expanding cases daily …

Discovery of potential multi-target-directed ligands by targeting host-specific SARS-CoV-2 structurally conserved main protease

RS Joshi, SS Jagdale, SB Bansode… - Journal of …, 2021 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in
the current COVID-19 pandemic. Worldwide this disease has infected over 2.5 million …

A molecular modeling approach to identify effective antiviral phytochemicals against the main protease of SARS-CoV-2

R Islam, MR Parves, AS Paul, N Uddin… - Journal of …, 2021 - Taylor & Francis
The main protease of SARS-CoV-2 is one of the important targets to design and develop
antiviral drugs. In this study, we have selected 40 antiviral phytochemicals to find out the …