Ovarian cancer screening: Current status and future directions
Z Nash, U Menon - Best practice & research Clinical obstetrics & …, 2020 - Elsevier
Ovarian cancer is the third most common gynaecological malignancy and the most lethal
worldwide. Most patients are diagnosed with advanced disease which carries significant …
worldwide. Most patients are diagnosed with advanced disease which carries significant …
Cancer genetics, precision prevention and a call to action
More than 15 years have passed since the identification, through linkage, of 'first-
wave'susceptibility genes for common cancers (BRCA1, BRCA2, MLH1 and MSH2). These …
wave'susceptibility genes for common cancers (BRCA1, BRCA2, MLH1 and MSH2). These …
CanRisk Tool—A web interface for the prediction of breast and ovarian cancer risk and the likelihood of carrying genetic pathogenic variants
T Carver, S Hartley, A Lee, AP Cunningham… - … , biomarkers & prevention, 2021 - AACR
Abstract Background: The CanRisk Tool (https://canrisk. org) is the next-generation web
interface for the latest version of the BOADICEA (Breast and Ovarian Analysis of Disease …
interface for the latest version of the BOADICEA (Breast and Ovarian Analysis of Disease …
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
CM Phelan, KB Kuchenbaecker, JP Tyrer, SP Kar… - Nature …, 2017 - nature.com
To identify common alleles associated with different histotypes of epithelial ovarian cancer
(EOC), we pooled data from multiple genome-wide genoty** projects totaling 25,509 EOC …
(EOC), we pooled data from multiple genome-wide genoty** projects totaling 25,509 EOC …
Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D
X Yang, H Song, G Leslie, C Engel… - JNCI: Journal of the …, 2020 - academic.oup.com
Background The purpose of this study was to estimate precise age-specific tubo-ovarian
carcinoma (TOC) and breast cancer (BC) risks for carriers of pathogenic variants in RAD51C …
carcinoma (TOC) and breast cancer (BC) risks for carriers of pathogenic variants in RAD51C …
Cost-effectiveness of population-based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 mutation testing in unselected general population women
Background The cost-effectiveness of population-based panel testing for high-and moderate-
penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We …
penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We …
The DNA methylome of cervical cells can predict the presence of ovarian cancer
The vast majority of epithelial ovarian cancer arises from tissues that are embryologically
derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in …
derived from the Müllerian Duct. Here, we demonstrate that a DNA methylation signature in …
Comprehensive epithelial tubo-ovarian cancer risk prediction model incorporating genetic and epidemiological risk factors
A Lee, X Yang, J Tyrer, A Gentry-Maharaj… - Journal of medical …, 2022 - jmg.bmj.com
Background Epithelial tubo-ovarian cancer (EOC) has high mortality partly due to late
diagnosis. Prevention is available but may be associated with adverse effects. A …
diagnosis. Prevention is available but may be associated with adverse effects. A …
Economic Evaluation of Population-Based BRCA1/BRCA2 Mutation Testing across Multiple Countries and Health Systems
R Manchanda, L Sun, S Patel, O Evans, J Wilschut… - Cancers, 2020 - mdpi.com
Clinical criteria/Family history-based BRCA testing misses a large proportion of BRCA
carriers who can benefit from screening/prevention. We estimate the cost-effectiveness of …
carriers who can benefit from screening/prevention. We estimate the cost-effectiveness of …
Enhancing the BOADICEA cancer risk prediction model to incorporate new data on RAD51C, RAD51D, BARD1 updates to tumour pathology and cancer incidence
A Lee, N Mavaddat, A Cunningham, T Carver… - Journal of medical …, 2022 - jmg.bmj.com
Background BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier
Estimation Algorithm) for breast cancer and the epithelial tubo-ovarian cancer (EOC) models …
Estimation Algorithm) for breast cancer and the epithelial tubo-ovarian cancer (EOC) models …