Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Nebulised unfractionated heparin (UFH) has a strong scientific and biological rationale and
warrants urgent investigation of its therapeutic potential, for COVID-19-induced acute …

Abstract The Corona Virus Disease (COVID-19) pandemic caused by Severe Acute
Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) requires a rapid solution and global …

Heparin is the earliest and most widely used anticoagulant and antithrombotic drug that is
still used in a variety of clinical indications. Since it was discovered in 1916, after more than …

Acute respiratory distress syndrome (ARDS) presents a complex pathophysiology
characterized by pulmonary activated coagulation and reduced fibrinolysis. Despite …

Introduction: Pharmacotherapy for the acute respiratory distress syndrome (ARDS) has been
tested in preclinical and clinical studies. However, to date, no pharmacological interventions …

Objective Alveolar macrophages play a key role in the development and resolution of acute
respiratory distress syndrome (ARDS), modulating the inflammatory response and the …

Background During acute respiratory distress syndrome, proinflammatory mediators inhibit
natural anticoagulant factors, which alter the normal balance between coagulation and …

Objective To examine and compare nebulizing heparin versus streptokinase for reversing
alveolar collapse nonresponsive to recruitment. Design A clinical trial at a tertiary intensive …

The defining features of acute respiratory distress syndrome (ARDS) are an excessive
inflammatory respiratory response associated with high morbidity and mortality. Treatment …