Introduction The steroid hormones constitute a very important class of compounds and are
present in most species. The hormones that are synthesized in the adrenal gland, namely …

In the pathways of steroid hormone biosynthesis there are two major types of enzymes:
cytochromes P450 and other steroid oxidoreductases. This review presents an overview of …

New textbooks at all levels of chemistry appear with great regularity. Some fields like basic
biochemistry, organic reaction mechanisms, and chemical thermody namics are well …

THAT the testes are related to the sexual characteristics of the individual and have
reproductive power was observed at an early time in history. One of the earliest descriptions …

Mitochondrial P450 type enzymes catalyze central steps in steroid biosynthesis, including
cholesterol conversion to pregnenolone, 11β and 18 hydroxylation in glucocorticoid and …

Cytochrome P450 enzymes catalyze the degradation of drugs and xenobiotics, but also
catalyze a wide variety of biosynthetic processes, including most steps in steroidogenesis …

Introduction T HE CYCLIC nature of the female reproductive process is largely dependent
upon the unique capability of the ovarian follicle to change in structure and function. A finely …

We show that cytochrome P450scc (CYP11A1) in either a reconstituted system or in isolated
adrenal mitochondria can metabolize vitamin D3. The major products of the reaction with …

Epithelial sodium channels (ENaCs) are located on the apical surface of cells and funnel
Na+ ions from the lumen into the cell. ENaC function also regulates extracellular fluid …

Cytochrome P450 was first found in the microsomes from animal tissues, and then the
presence of P450 in mitochondria was reported for the steroidogenic organs, adrenal gland …