Severe childhood malnutrition

ZA Bhutta, JA Berkley, RHJ Bandsma… - Nature reviews Disease …, 2017 - nature.com
The main forms of childhood malnutrition occur predominantly in children< 5 years of age
living in low-income and middle-income countries and include stunting, wasting and …

Nutrition, infection and stunting: the roles of deficiencies of individual nutrients and foods, and of inflammation, as determinants of reduced linear growth of children

DJ Millward - Nutrition research reviews, 2017 - cambridge.org
The regulation of linear growth by nutritional and inflammatory influences is examined in
terms of growth-plate endochondral ossification, in order to better understand stunted growth …

Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency

A Rodríguez‐Nuevo, A Díaz‐Ramos, E Noguera… - The EMBO …, 2018 - embopress.org
Opa1 participates in inner mitochondrial membrane fusion and cristae morphogenesis.
Here, we show that muscle‐specific Opa1 ablation causes reduced muscle fiber size …

[HTML][HTML] Systemic inflammation, growth factors, and linear growth in the setting of infection and malnutrition

MD DeBoer, RJ Scharf, AM Leite, A Férrer, A Havt… - Nutrition, 2017 - Elsevier
Objectives Deficits in weight gain and linear growth are seen frequently among children in
areas where malnutrition and recurrent infections are common. Although both inflammation …

IGF-1 and IGFBP-3 in Inflammatory Cachexia

AI Martín, T Priego, Á Moreno-Ruperez… - International Journal of …, 2021 - mdpi.com
Inflammation induces a wide response of the neuroendocrine system, which leads to
modifications in all the endocrine axes. The hypothalamic–growth hormone (GH)–insulin …

Inflammatory diseases and growth: effects on the GH–IGF axis and on growth plate

F Cirillo, P Lazzeroni, C Sartori, ME Street - International Journal of …, 2017 - mdpi.com
This review briefly describes the most common chronic inflammatory diseases in childhood,
such as cystic fibrosis (CF), inflammatory bowel diseases (IBDs), juvenile idiopathic arthritis …

Growth and puberty in children with juvenile idiopathic arthritis

DM d'Angelo, G Di Donato, L Breda, F Chiarelli - Pediatric Rheumatology, 2021 - Springer
Abstract Juvenile Idiopathic Arthritis is one of the most prevalent chronic diseases in
children, with an annual incidence of 2–20 cases per 100,000 and a prevalence of 16–150 …

The associations of gut microbiota, endocrine system and bone metabolism

Y Tu, X Kuang, L Zhang, X Xu - Frontiers in Microbiology, 2023 - frontiersin.org
Gut microbiota is of great importance in human health, and its roles in the maintenance of
skeletal homeostasis have long been recognized as the “gut-bone axis.” Recent evidence …

Can exercise affect the course of inflammatory bowel disease? Experimental and clinical evidence

J Bilski, A Mazur-Bialy, B Brzozowski… - Pharmacological …, 2016 - Elsevier
The inflammatory bowel disease (IBD) consisting of Crohn's disease (CD) and ulcerative
colitis (UC) are defined as idiopathic, chronic and relapsing intestinal disorders occurring in …

Insulin‐like growth factor‐1 signaling in lung development and inflammatory lung diseases

Z Wang, W Li, Q Guo, Y Wang, L Ma… - BioMed research …, 2018 - Wiley Online Library
Insulin‐like growth factor‐1 (IGF‐1) was firstly identified as a hormone that mediates the
biological effects of growth hormone. Accumulating data have indicated the role of IGF‐1 …