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Bacterial persisters: molecular mechanisms and therapeutic development
H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
Antibiotic resistance and persistence—Implications for human health and treatment perspectives
Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …
treatment failure and relapsing infections. They are thus important drivers of increased …
Teixobactin kills bacteria by a two-pronged attack on the cell envelope
Antibiotics that use novel mechanisms are needed to combat antimicrobial resistance,–.
Teixobactin represents a new class of antibiotics with a unique chemical scaffold and lack of …
Teixobactin represents a new class of antibiotics with a unique chemical scaffold and lack of …
Multimodal nanoimmunotherapy engages neutrophils to eliminate Staphylococcus aureus infections
The increasing prevalence of antimicrobial resistance in Staphylococcus aureus
necessitates alternative therapeutic approaches. Neutrophils play a crucial role in the fight …
necessitates alternative therapeutic approaches. Neutrophils play a crucial role in the fight …
[HTML][HTML] The science of antibiotic discovery
K Lewis - Cell, 2020 - cell.com
We are experiencing an antimicrobial resistance (AMR) crisis, brought on by the drying up of
the antibiotic discovery pipeline and the resulting unchecked spread of resistant pathogens …
the antibiotic discovery pipeline and the resulting unchecked spread of resistant pathogens …
NIR‐II Photo‐Amplified Sonodynamic Therapy Using Sodium Molybdenum Bronze Nanoplatform against Subcutaneous Staphylococcus Aureus Infection
Ultrasound (US)‐mediated sonodynamic therapy (SDT) has the advantages of non‐
invasiveness and deep tissue penetration. Nanosystems are prominently used in …
invasiveness and deep tissue penetration. Nanosystems are prominently used in …
[HTML][HTML] Antimicrobial mechanisms and clinical application prospects of antimicrobial peptides
X Li, S Zuo, B Wang, K Zhang, Y Wang - Molecules, 2022 - mdpi.com
Antimicrobial peptides are a type of small-molecule peptide that widely exist in nature and
are components of the innate immunity of almost all living things. They play an important role …
are components of the innate immunity of almost all living things. They play an important role …
Targeting microbial biofilms: current and prospective therapeutic strategies
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause
chronic infections. The multifactorial nature of biofilm development and drug tolerance …
chronic infections. The multifactorial nature of biofilm development and drug tolerance …
Effect of tolerance on the evolution of antibiotic resistance under drug combinations
Drug combinations are widely used in clinical practice to prevent the evolution of resistance.
However, little is known about the effect of tolerance, a different mode of survival, on the …
However, little is known about the effect of tolerance, a different mode of survival, on the …
Emerging challenges in antimicrobial resistance: implications for pathogenic microorganisms, novel antibiotics, and their impact on sustainability
Overuse of antibiotics is accelerating the antimicrobial resistance among pathogenic
microbes which is a growing public health challenge at the global level. Higher resistance …
microbes which is a growing public health challenge at the global level. Higher resistance …