Bacterial persisters: molecular mechanisms and therapeutic development

H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

Antibiotic resistance and persistence—Implications for human health and treatment perspectives

M Huemer, S Mairpady Shambat, SD Brugger… - EMBO …, 2020 - embopress.org
Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …

Teixobactin kills bacteria by a two-pronged attack on the cell envelope

R Shukla, F Lavore, S Maity, MGN Derks, CR Jones… - Nature, 2022 - nature.com
Antibiotics that use novel mechanisms are needed to combat antimicrobial resistance,–.
Teixobactin represents a new class of antibiotics with a unique chemical scaffold and lack of …

Multimodal nanoimmunotherapy engages neutrophils to eliminate Staphylococcus aureus infections

J Zhu, R **e, R Gao, Y Zhao, N Yodsanit, M Zhu… - Nature …, 2024 - nature.com
The increasing prevalence of antimicrobial resistance in Staphylococcus aureus
necessitates alternative therapeutic approaches. Neutrophils play a crucial role in the fight …

[HTML][HTML] The science of antibiotic discovery

K Lewis - Cell, 2020 - cell.com
We are experiencing an antimicrobial resistance (AMR) crisis, brought on by the drying up of
the antibiotic discovery pipeline and the resulting unchecked spread of resistant pathogens …

NIR‐II Photo‐Amplified Sonodynamic Therapy Using Sodium Molybdenum Bronze Nanoplatform against Subcutaneous Staphylococcus Aureus Infection

X He, JT Hou, X Sun, P Jangili, J An… - Advanced Functional …, 2022 - Wiley Online Library
Ultrasound (US)‐mediated sonodynamic therapy (SDT) has the advantages of non‐
invasiveness and deep tissue penetration. Nanosystems are prominently used in …

[HTML][HTML] Antimicrobial mechanisms and clinical application prospects of antimicrobial peptides

X Li, S Zuo, B Wang, K Zhang, Y Wang - Molecules, 2022 - mdpi.com
Antimicrobial peptides are a type of small-molecule peptide that widely exist in nature and
are components of the innate immunity of almost all living things. They play an important role …

Targeting microbial biofilms: current and prospective therapeutic strategies

H Koo, RN Allan, RP Howlin, P Stoodley… - Nature Reviews …, 2017 - nature.com
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause
chronic infections. The multifactorial nature of biofilm development and drug tolerance …

Effect of tolerance on the evolution of antibiotic resistance under drug combinations

J Liu, O Gefen, I Ronin, M Bar-Meir, NQ Balaban - Science, 2020 - science.org
Drug combinations are widely used in clinical practice to prevent the evolution of resistance.
However, little is known about the effect of tolerance, a different mode of survival, on the …

Emerging challenges in antimicrobial resistance: implications for pathogenic microorganisms, novel antibiotics, and their impact on sustainability

S Sharma, A Chauhan, A Ranjan, DM Mathkor… - Frontiers in …, 2024 - frontiersin.org
Overuse of antibiotics is accelerating the antimicrobial resistance among pathogenic
microbes which is a growing public health challenge at the global level. Higher resistance …