Cancer immunotherapy offers substantive benefit to patients with various tumour types, in
some cases leading to complete tumour clearance. However, many patients do not respond …

T cells engineered to express chimeric antigen receptors (CARs) that are specific for tumour
antigens have led to high complete response rates in patients with haematologic …

MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene
regulators in various neuronal degenerative diseases and playact a key role in these …

The prevalence of overweight and obesity in developed and develo** countries has
greatly increased the risk of insulin resistance and type 2 diabetes mellitus. It is evident from …

The discovery of microRNA (miRNA) sorting into extracellular vesicles (EVs) revealed a
novel mode of intercellular communication and uncovered a link between cellular …

Originally described over a decade ago as a T cell transcription factor regulating T helper 1
cell lineage commitment, T-bet is now recognized as having an important role in many cells …

Stem cells are defined by the ability to self-renew and to generate differentiated progeny,
qualities that are maintained by evolutionarily conserved pathways that can lead to cancer …

MicroRNAs (miRNA) are small non-coding RNAs (∼ 22 nt in length) that are known as
potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a …

Abstract CD4+ T helper (TH) cells regulate appropriate cellular and humoral immune
responses to a wide range of pathogens and are central to the success of vaccines …

MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as
post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the …