Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new
drugs with novel modes of action and thus considerable research has been conducted for …

Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …

The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …

Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …

Natural products (NPs) are a rich source of novel compound classes and new drugs. In the
present study we have used the chemical space navigation tool ChemGPS-NP to evaluate …

The concept of chemical space is a cornerstone in chemoinformatics, and it has broad
conceptual and practical applicability in many areas of chemistry, including drug design and …

Background During evolution, plants and other organisms have developed a diversity of
chemical defences, leading to the evolution of various groups of specialized metabolites …

Marine cyanobacteria are an ancient group of photosynthetic microbes dating back to 3.5
million years ago. They are prolific producers of bioactive secondary metabolites. Over …

Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and
members of this class have been in clinical use for more than 1500 years. They have been …

Importance to the field: Natural products are the most consistently successful source of drug
leads, both historically and currently. Despite this, the use of natural products in industrial …