Diabetes, metabolic disease, and telomere length

F Cheng, L Carroll, MV Joglekar… - The Lancet Diabetes & …, 2021 - thelancet.com
Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes.
Telomere length is a marker of DNA damage, which is often considered a biomarker for …

Obesity: a perfect storm for carcinogenesis

BHL Harris, VM Macaulay, DA Harris… - Cancer and Metastasis …, 2022 - Springer
Obesity-related cancers account for 40% of the cancer cases observed in the USA and
obesity is overtaking smoking as the most widespread modifiable risk factor for …

Association between the oxidative balance score and telomere length from the National Health and Nutrition Examination Survey 1999‐2002

W Zhang, SF Peng, L Chen, HM Chen… - Oxidative medicine …, 2022 - Wiley Online Library
Purpose. Leukocyte telomere length (LTL) is an important biomarker of aging. The oxidative
balance score (OBS) is used to assess the oxidative stress‐related exposures of diet and …

Lifespan Perspective on Congenital Heart Disease Research: JACC State-of-the-Art Review

GP Diller, A Arvanitaki, AR Opotowsky… - Journal of the American …, 2021 - jacc.org
More than 90% of patients with congenital heart disease (CHD) are nowadays surviving to
adulthood and adults account for over two-thirds of the contemporary CHD population in …

Effect of long‐term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis

WJ Hastings, Q Ye, SE Wolf, CP Ryan, SK Das… - Aging …, 2024 - Wiley Online Library
Caloric restriction (CR) modifies lifespan and aging biology in animal models. The
Comprehensive Assessment of Long‐Term Effects of Reducing Intake of Energy …

Genetic evidence for causal effects of socioeconomic, lifestyle, and cardiometabolic factors on epigenetic-age acceleration

L Kong, C Ye, Y Wang, T Hou, J Zheng… - The Journals of …, 2023 - academic.oup.com
Abstract GrimAge acceleration (GrimAgeAccel) and PhenoAge acceleration
(PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging …

Modifiable traits, healthy behaviours, and leukocyte telomere length: a population-based study in UK Biobank

V Bountziouka, C Musicha, E Allara… - The Lancet Healthy …, 2022 - thelancet.com
Background Telomere length is associated with risk of several age-related diseases and
cancers. We aimed to investigate the extent to which telomere length might be modifiable …

Associations of body composition and physical activity level with multiple measures of epigenetic age acceleration

JK Kresovich, EL Garval… - American journal of …, 2021 - academic.oup.com
Epigenetic clocks use DNA methylation to estimate biological age. Whether body
composition and physical activity are associated with these clocks is not well understood …

An integrative study of five biological clocks in somatic and mental health

R Jansen, LKM Han, JE Verhoeven, KA Aberg… - Elife, 2021 - elifesciences.org
Biological clocks have been developed at different molecular levels and were found to be
more advanced in the presence of somatic illness and mental disorders. However, it is …

Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications

GR Fries, MJ Zamzow, T Andrews, O Pink… - Neuroscience & …, 2020 - Elsevier
Bipolar disorder (BD) has been associated with clinical signs of accelerated aging, which
potentially underlies its association with several age-related medical conditions, such as …