Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

M Xu, Y Qi, G Liu, Y Song, X Jiang, B Du - ACS nano, 2023 - ACS Publications
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

Lymphoid organ-targeted nanomaterials for immunomodulation of cancer, inflammation, and beyond

JC Hsu, P Liu, Y Song, W Song, RJ Saladin… - Chemical Society …, 2024 - pubs.rsc.org
Nanomaterials exhibit significant potential for stimulating immune responses, offering both
local and systemic modulation across a variety of diseases. The lymphoid organs, such as …

Multicomponent synthesis of imidazole-based ionizable lipids for highly efficient and spleen-selective messenger RNA delivery

W Dong, Z Li, T Hou, Y Shen, Z Guo… - Journal of the …, 2024 - ACS Publications
The spleen emerges as a pivotal target for mRNA delivery, prompting a continual quest for
specialized and efficient lipid nanoparticles (LNPs) designed to enhance spleen-selective …

H2S-Reactivating Antitumor Immune Response after Microwave Thermal Therapy for Long-Term Tumor Suppression

S Li, F Xu, X Ren, L Tan, C Fu, Q Wu, Z Chen, J Ren… - ACS …, 2023 - ACS Publications
Microwave thermal therapy (MWTT) is one of the most potent ablative treatments known,
with advantages like deep penetration, minimal invasion, repeatable operation, and low …

Advancements in hydrogel-based drug delivery systems for the treatment of inflammatory bowel disease: a review

Y Liu, J Huang, S Li, Z Li, C Chen, G Qu, K Chen… - Biomaterials …, 2024 - pubs.rsc.org
Inflammatory bowel disease (IBD) is a chronic disorder that affects millions of individuals
worldwide. However, current drug therapies for IBD are plagued by significant side effects …

Recent advances on emerging nanomaterials for diagnosis and treatment of inflammatory bowel disease

W Fu, L Xu, Z Chen, L Kan, Y Ma, H Qian… - Journal of Controlled …, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory disorder that affects
the entire gastrointestinal tract and is associated with an increased risk of colorectal cancer …

Inhibiting the cGAS-STING pathway in ulcerative colitis with programmable micelles

S Uthaman, S Parvinroo, AP Mathew, X Jia… - ACS …, 2024 - ACS Publications
Ulcerative colitis is a chronic condition in which a dysregulated immune response
contributes to the acute intestinal inflammation of the colon. Current clinical therapies often …

AH2S‐Generated Supramolecular Photosensitizer for Enhanced Photodynamic Antibacterial Infection and Relieving Inflammation

J Tian, B Huang, L **a, Y Zhu, W Zhang - Advanced Science, 2024 - Wiley Online Library
Photodynamic therapy (PDT) is a promising treatment against bacteria‐caused infections.
By producing large amounts of reactive oxygen species (ROS), PDT can effectively eliminate …

Spleen-targeted delivery systems and strategies for spleen-related diseases

Z Huang, K Sun, Z Luo, J Zhang, H Zhou, H Yin… - Journal of Controlled …, 2024 - Elsevier
The spleen, body's largest secondary lymphoid organ, is also a vital hematopoietic and
immunological organ. It is regarded as one of the most significant organs in humans. As …

[HTML][HTML] Anti-inflammatory effects of dietary polyphenols through inhibitory activity against metalloproteinases

T Suzuki, T Ohishi, H Tanabe, N Miyoshi, Y Nakamura - Molecules, 2023 - mdpi.com
Matrix metalloproteinases (MMPs) are zinc-dependent metalloproteinases that play
important roles in a variety of diseases, including cancer, cardiovascular disease, diabetes …