Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

[HTML][HTML] Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities

VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …

[HTML][HTML] Regulation of Nrf2 by mitochondrial reactive oxygen species in physiology and pathology

S Kasai, S Shimizu, Y Tatara, J Mimura, K Itoh - Biomolecules, 2020 - mdpi.com
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling
molecules that control various cellular functions. Nrf2 governs the gene expression of …

Chronic inflammation and cancer; the two sides of a coin

Q Fernandes, VP Inchakalody, T Bedhiafi, S Mestiri… - Life Sciences, 2024 - Elsevier
The correlation between chronic inflammation and cancer was initially identified in the 19th
century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors …

Targeting aging mechanisms: pharmacological perspectives

A Moskalev, Z Guvatova, IDA Lopes, CW Beckett… - Trends in Endocrinology …, 2022 - cell.com
Geroprotectors slow down aging and promote healthy longevity in model animals. Although
hundreds of compounds have been shown to extend the life of laboratory model organisms …

[HTML][HTML] The hyperoxic-hypoxic paradox

A Hadanny, S Efrati - Biomolecules, 2020 - mdpi.com
Effective metabolism is highly dependent on a narrow therapeutic range of oxygen.
Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene …

[HTML][HTML] The effects of ketogenic diet on insulin sensitivity and weight loss, which came first: the chicken or the egg?

A Paoli, A Bianco, T Moro, JF Mota… - Nutrients, 2023 - mdpi.com
The ketogenic diet (KD) is, nowadays, considered an interesting nutritional approach for
weight loss and improvement in insulin resistance. Nevertheless, most of the studies …

Redox signaling at the crossroads of human health and disease

J Zuo, Z Zhang, M Luo, L Zhou, EC Nice, W Zhang… - MedComm, 2022 - Wiley Online Library
Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …

Mitochondrial dynamics: fission and fusion in fate determination of mesenchymal stem cells

L Ren, X Chen, X Chen, J Li, B Cheng… - Frontiers in cell and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration
due to their potential for self-renewal, multilineage differentiation, and immune modulation …

[HTML][HTML] Macrophage polarization mediated by mitochondrial dysfunction induces adipose tissue inflammation in obesity

L Xu, X Yan, Y Zhao, J Wang, B Liu, S Yu, J Fu… - International journal of …, 2022 - mdpi.com
Obesity is one of the prominent global health issues, contributing to the growing prevalence
of insulin resistance and type 2 diabetes. Chronic inflammation in adipose tissue is …