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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …
[HTML][HTML] Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities
VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …
[HTML][HTML] Regulation of Nrf2 by mitochondrial reactive oxygen species in physiology and pathology
S Kasai, S Shimizu, Y Tatara, J Mimura, K Itoh - Biomolecules, 2020 - mdpi.com
Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling
molecules that control various cellular functions. Nrf2 governs the gene expression of …
molecules that control various cellular functions. Nrf2 governs the gene expression of …
Chronic inflammation and cancer; the two sides of a coin
The correlation between chronic inflammation and cancer was initially identified in the 19th
century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors …
century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors …
Targeting aging mechanisms: pharmacological perspectives
Geroprotectors slow down aging and promote healthy longevity in model animals. Although
hundreds of compounds have been shown to extend the life of laboratory model organisms …
hundreds of compounds have been shown to extend the life of laboratory model organisms …
[HTML][HTML] The hyperoxic-hypoxic paradox
A Hadanny, S Efrati - Biomolecules, 2020 - mdpi.com
Effective metabolism is highly dependent on a narrow therapeutic range of oxygen.
Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene …
Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene …
[HTML][HTML] The effects of ketogenic diet on insulin sensitivity and weight loss, which came first: the chicken or the egg?
The ketogenic diet (KD) is, nowadays, considered an interesting nutritional approach for
weight loss and improvement in insulin resistance. Nevertheless, most of the studies …
weight loss and improvement in insulin resistance. Nevertheless, most of the studies …
Redox signaling at the crossroads of human health and disease
Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …
processes with biological activities. Redox homeostasis is a prerequisite for human health …
Mitochondrial dynamics: fission and fusion in fate determination of mesenchymal stem cells
L Ren, X Chen, X Chen, J Li, B Cheng… - Frontiers in cell and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration
due to their potential for self-renewal, multilineage differentiation, and immune modulation …
due to their potential for self-renewal, multilineage differentiation, and immune modulation …
[HTML][HTML] Macrophage polarization mediated by mitochondrial dysfunction induces adipose tissue inflammation in obesity
L Xu, X Yan, Y Zhao, J Wang, B Liu, S Yu, J Fu… - International journal of …, 2022 - mdpi.com
Obesity is one of the prominent global health issues, contributing to the growing prevalence
of insulin resistance and type 2 diabetes. Chronic inflammation in adipose tissue is …
of insulin resistance and type 2 diabetes. Chronic inflammation in adipose tissue is …