Cardiac fibrosis

NG Frangogiannis - Cardiovascular research, 2021 - academic.oup.com
Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Inflammation in Heart Failure: JACC State-of-the-Art Review

SP Murphy, R Kakkar, CP McCarthy… - Journal of the American …, 2020 - jacc.org
It has long been observed that heart failure (HF) is associated with measures of systemic
inflammation. In recent years, there have been significant advancements in our …

Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection

CB Messner, V Demichev, D Wendisch, L Michalick… - Cell systems, 2020 - cell.com
The COVID-19 pandemic is an unprecedented global challenge, and point-of-care
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high …

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities

NG Frangogiannis - Molecular aspects of medicine, 2019 - Elsevier
Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Role of biomarkers for the prevention, assessment, and management of heart failure: a scientific statement from the American Heart Association

SL Chow, AS Maisel, I Anand, B Bozkurt, RA De Boer… - Circulation, 2017 - ahajournals.org
Background and Purpose: Natriuretic peptides have led the way as a diagnostic and
prognostic tool for the diagnosis and management of heart failure (HF). More recent …

Heart failure with preserved ejection fraction: from mechanisms to therapies

CSP Lam, AA Voors, RA de Boer… - European heart …, 2018 - academic.oup.com
This review aims to provide a translational perspective on recent developments in heart
failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential …