Oxidative stress and antioxidants in neurodegenerative disorders

EO Olufunmilayo, MB Gerke-Duncan, RMD Holsinger - Antioxidants, 2023 - mdpi.com
Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …

Mitochondrial dysfunction in Parkinson's disease–a key disease hallmark with therapeutic potential

MT Henrich, WH Oertel, DJ Surmeier… - Molecular …, 2023 - Springer
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

[HTML][HTML] Ferroptosis in Parkinson's disease: glia–neuron crosstalk

ZL Wang, L Yuan, W Li, JY Li - Trends in molecular medicine, 2022 - cell.com
Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the
formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is …

Progress towards therapies for disease modification in Parkinson's disease

N Vijiaratnam, T Simuni, O Bandmann… - The Lancet …, 2021 - thelancet.com
The development of interventions to slow or halt the progression of Parkinson's disease
remains a priority for patients and researchers alike. To date, no agents have been shown to …

Ferroptosis in Parkinson's disease: molecular mechanisms and therapeutic potential

X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …

Parkinson disease

R Balestrino, AHV Schapira - European journal of neurology, 2020 - Wiley Online Library
Parkinson disease (PD) is the most common neurodegenerative movement disorder. In
Europe, prevalence and incidence rates for PD are estimated at approximately 108–257/100 …

[HTML][HTML] Glutathione in the Brain

K Aoyama - International journal of molecular sciences, 2021 - mdpi.com
Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the
antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH …

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

BG Trist, DJ Hare, KL Double - Aging cell, 2019 - Wiley Online Library
Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …

Ferroptosis and its potential role in the physiopathology of Parkinson's Disease

L Mahoney-Sánchez, H Bouchaoui, S Ayton… - Progress in …, 2021 - Elsevier
Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

Parkinson's disease: Mechanisms, translational models and management strategies

C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …