CD8+ T cells in HIV control, cure and prevention
HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …
Acute human immunodeficiency virus type 1 infection
JO Kahn, BD Walker - New England Journal of Medicine, 1998 - Mass Medical Soc
Acute human immunodeficiency virus type 1 (HIV-1) infection is a transient symptomatic
illness associated with high-titer HIV-1 replication and a robust and expansive immunologic …
illness associated with high-titer HIV-1 replication and a robust and expansive immunologic …
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Functional impairment of T cells is characteristic of many chronic mouse and human viral
infections. The inhibitory receptor programmed death 1 (PD-1; also known as PDCD1), a …
infections. The inhibitory receptor programmed death 1 (PD-1; also known as PDCD1), a …
Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans
Protective immunity against influenza virus infection is mediated by neutralizing antibodies,
but the precise role of T cells in human influenza immunity is uncertain. We conducted …
but the precise role of T cells in human influenza immunity is uncertain. We conducted …
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
Cytotoxic T lymphocytes (CTLs) lyse virally infected cells that display viral peptide epitopes
in association with major histocompatibility complex (MHC) class I molecules on the cell …
in association with major histocompatibility complex (MHC) class I molecules on the cell …
Virus dynamics and drug therapy
The recent development of potent antiviral drugs not only has raised hopes for effective
treatment of infections with HIV or the hepatitis B virus, but also has led to important …
treatment of infections with HIV or the hepatitis B virus, but also has led to important …
HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
A Sáez-Cirión, C Lacabaratz… - Proceedings of the …, 2007 - National Acad Sciences
Some rare HIV-1-infected individuals, referred to as HIV controllers (HIC), have persistently
undetectable plasma viral load in the absence of therapy. This control of HIV-1 replication …
undetectable plasma viral load in the absence of therapy. This control of HIV-1 replication …
Cellular immune responses to HIV
AJ McMichael, SL Rowland-Jones - Nature, 2001 - nature.com
The cellular immune response to the human immunodeficiency virus, mediated by T
lymphocytes, seems strong but fails to control the infection completely. In most virus …
lymphocytes, seems strong but fails to control the infection completely. In most virus …
Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy
T Pierson, J McArthur… - Annual review of …, 2000 - annualreviews.org
The success of combination antiretroviral therapy for HIV-1 infection has generated interest
in mechanisms by which the virus can persist in the body despite the presence of drugs that …
in mechanisms by which the virus can persist in the body despite the presence of drugs that …
The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses
For many viral infections, resolution of illness is associ-ated with long-term host control of
viremia rather than viral eradication. An example is EBV infection, and the fact that host …
viremia rather than viral eradication. An example is EBV infection, and the fact that host …