Leucine supplementation in cancer cachexia: mechanisms and a review of the pre-clinical literature
AG Beaudry, ML Law - Nutrients, 2022 - mdpi.com
Cancer cachexia (CC) is a complex syndrome of bodily wasting and progressive functional
decline. Unlike starvation, cachexia cannot be reversed by increased energy intake alone …
decline. Unlike starvation, cachexia cannot be reversed by increased energy intake alone …
The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment
D Aguilar-Cazares, R Chavez-Dominguez… - Frontiers in …, 2022 - frontiersin.org
The tumor microenvironment is a dynamic, complex, and redundant network of interactions
between tumor, immune, and stromal cells. In this intricate environment, cells communicate …
between tumor, immune, and stromal cells. In this intricate environment, cells communicate …
Lipid nanoparticles elicit reactogenicity and sickness behavior in mice via toll-like receptor 4 and myeloid differentiation protein 88 axis
mRNA therapeutics encapsulated in lipid nanoparticles (LNPs) offer promising avenues for
treating various diseases. While mRNA vaccines anticipate immunogenicity, the associated …
treating various diseases. While mRNA vaccines anticipate immunogenicity, the associated …
[HTML][HTML] Cancer cachexia: involvement of an expanding macroenvironment
Advanced cancers often present with the cachexia syndrome that impacts peripheral tissues,
leading to involuntary weight loss and reduced prognosis. The central tissues undergoing …
leading to involuntary weight loss and reduced prognosis. The central tissues undergoing …
Addressing unmet needs for people with cancer cachexia: recommendations from a multistakeholder workshop
1Department of Medicine, Division of Geriatrics, University of Washington and Geriatric
Research Education and Clinical Center, Puget Sound Veterans Administration Health Care …
Research Education and Clinical Center, Puget Sound Veterans Administration Health Care …
The area postrema: a critical mediator of brain–body interactions
The dorsal vagal complex contains three structures: the area postrema, the nucleus tractus
solitarii, and the dorsal motor nucleus of the vagus. These structures are tightly linked, both …
solitarii, and the dorsal motor nucleus of the vagus. These structures are tightly linked, both …
[HTML][HTML] Central neural mechanisms of cancer cachexia
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Targeting cancer cachexia: Molecular mechanisms and clinical study
Cancer cachexia is a complex systemic catabolism syndrome characterized by muscle
wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer …
wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer …
A waste product's unexpected role in wasting
JD Sanford, MD Goncalves - Nature Metabolism, 2024 - nature.com
A waste product’s unexpected role in wasting | Nature Metabolism Skip to main content Thank
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Area postrema neurons mediate interleukin-6 function in cancer cachexia
Abstract Interleukin-6 (IL-6) has been long considered a key player in cancer cachexia. It is
believed that sustained elevation of IL-6 production during cancer progression causes brain …
believed that sustained elevation of IL-6 production during cancer progression causes brain …