Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal
feature of astrocytes is their complex and visually enchanting morphology, referred to as …

Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

Secreted and membrane-tethered mammalian neuromodulators from the Ly6/uPAR family
are involved in regulation of many physiological processes. Some of them are expressed in …

Highlights•Neurodevelopmental disorders (NDDs) arise from errors in synaptic circuit
development.•Astrocytes communicate bidirectionally with neurons to control synapse …

Astrocytes are multifaceted glial cell types that perform structural, functional, metabolic, and
homeostatic roles in the brain. Recent studies have revealed mechanisms underlying the …

In recent decades, there has been a dramatic rise in the rates of children being born after in
utero exposure to drugs of abuse, particularly opioids. Opioids have been shown to have …

Dysfunctional mitochondrial dynamics are a hallmark of devastating neurodevelopmental
disorders such as childhood refractory epilepsy. However, the role of glial mitochondria in …

Adherens junctions (AJs) are a fundamental organizing structure for multicellular life.
Although AJs are studied mainly in epithelia, their core function–stabilizing cell contacts by …

Background Cerebral cavernous malformation (CCM) is a low-flow, bleeding-prone vascular
disease that can cause cerebral hemorrhage, seizure and neurological deficits. Its …

This chapter explores the intricate interactions between neurons and astrocytes within the
nervous system with a particular emphasis on studies conducted in human tissue or with …