Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …

The type VI secretion systems (T6SS) are present in about a quarter of all Gram-negative
bacteria. Several key components of T6SS are evolutionarily related to components of …

Type VI secretion systems (T6SSs) are macromolecular assemblies that deliver toxic effector
proteins between adjacent bacteria. These effectors span a wide range of protein families …

SPHIRE (SPARX for High-Resolution Electron Microscopy) is a novel open-source, user-
friendly software suite for the semi-automated processing of single particle electron cryo …

Teneurins are ancient metazoan cell adhesion receptors that control brain development and
neuronal wiring in higher animals. The extracellular C terminus binds the adhesion GPCR …

The design of protein sequences that fold into prescribed de novo structures is challenging.
General solutions to this problem require geometric descriptions of protein folds and …

Bacterial ADP-ribosyltransferase toxins (bARTTs) transfer ADP-ribose to eukaryotic proteins
to promote bacterial pathogenesis. In this Review, we use prototype bARTTs, such as …

Teneurins (TENs) are cell-surface adhesion proteins with critical roles in tissue development
and axon guidance. Here, we report the 3.1-Å cryoelectron microscopy structure of the …

The control of insects of medical importance, such as Aedes aegypti and Aedes albopictus
are still the only effective way to prevent the transmission of diseases, such as dengue …

The type VI secretion system (T6SS) is a lethal weapon used by many bacteria to kill
eukaryotic predators or prokaryotic competitors. Killing by the T6SS results from repetitive …