The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye
disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears …

The precorneal tear film is a complex mixture of proteins, lipids, metabolites, and electrolytes
with different structures and functionalities. Sustainable production of each tear component …

Purpose: This review is intended to bring to the informed reader the current state of
knowledge about meibomian lipids and the art for analyzing them. Methods: At the forefront …

This review highlights recent findings that describ how purines modulate the physiological
and pathophysiological responses of ocular tissues. For example, in lacrimal glands the …

Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the
quality or quantity of the precorneal tear film. It is considered one of the most common ocular …

Adenosine triphosphate (ATP), an energy source currency in cells, is released or leaked to
the extracellular space under both physiological and pathological conditions. Extracellular …

Recent advances in the understanding of dry eye disease (DED) have revealed previously
unexplored targets for drug therapy. One of these drugs is diquafosol, a uridine nucleotide …

Purpose: To compare signs and symptoms of dry eye in keratoconus (KC) patients versus
healthy subjects. Methods: A total of 15 KC patients (KC group, n= 15 eyes) and 16 healthy …

Dry eye disease (DED) is a chronic, multifactorial ocular surface disorder with multiple
etiologies that results in tear film instability. Globally, the prevalence of DED is expected to …

PURPOSE: To investigate the incidence of severe dry eye syndrome (DES) after external
beam radiotherapy for head-and-neck cancer and its dependence on the parameters …