Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Angiogenesis is a hallmark of cancer and is required for tumor growth and progression.
Antiangiogenic therapy has been revolutionarily develo** and was approved for the …

Solute carriers of the glucose transporter (GLUT) family mediate the first step for cellular
glucose usage. The upregulation of GLUT s has been reported in numerous cancer types as …

Cancer treatment with either standard chemotherapy or targeted agents often results in the
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The …

The Warburg effect is a tumor-related phenomenon that could potentially be targeted
therapeutically. Here, we showed that glioblastoma (GBM) cultures and patients' tumors …

In 2021 the World Health Organization published the fifth and latest version of the Central
Nervous System tumors classification, which incorporates and summarizes a long list of …

Tumor metabolism is emerging as a potential target for cancer therapies. This new approach
holds particular promise for the treatment of glioblastoma, a highly lethal brain tumor that is …

Metabolic reprogramming is associated with resistance to antiangiogenic therapy in cancer.
However, its molecular mechanisms have not been clearly elucidated. Here, we identify the …

Reprogramming of cellular energy metabolism is widely accepted to be a cancer hallmark.
The deviant energetic metabolism of cancer cells-known as the Warburg effect-consists in …