Modulation of the cAMP signaling pathway after traumatic brain injury
Traumatic brain injury (TBI) results in both focal and diffuse brain pathologies that are
exacerbated by the inflammatory response and progress from hours to days after the initial …
exacerbated by the inflammatory response and progress from hours to days after the initial …
Creatine-enhanced diet alters levels of lactate and free fatty acids after experimental brain injury
SW Scheff, HS Dhillon - Neurochemical research, 2004 - Springer
Free fatty acids (FFA) and lactic acid are markers of secondary cellular injury following
traumatic brain injury (TBI). We previously showed that animals fed a creatine (Cr)-enriched …
traumatic brain injury (TBI). We previously showed that animals fed a creatine (Cr)-enriched …
Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast
Due to recent military conflicts and terrorist attacks, blast-induced traumatic brain injury
(bTBI) presents a health concern for military and civilian personnel alike. Although …
(bTBI) presents a health concern for military and civilian personnel alike. Although …
Benzamidine derivatives and their use as anti-coagulants
BO Buckman, DD Davey, WJ Guilford… - US Patent …, 2001 - Google Patents
This invention is directed to benZamidine derivatives which are useful as anti-coagulants.
This invention is also directed to pharmaceutical compositions containing the compounds of …
This invention is also directed to pharmaceutical compositions containing the compounds of …
Severity of experimental brain injury on lactate and free fatty acid accumulation and Evans blue extravasation in the rat cortex and hippocampus
HS Dhillon, HM Carman, D Zhang, SW Scheff… - Journal of …, 1999 - liebertpub.com
Lactate and free fatty acids (FFAs) were extracted from the cortices and hippocampi of rats
subjected to sham operation, or mild (1.25 atm) or moderate (2.0 atm) fluid percussion (FP) …
subjected to sham operation, or mild (1.25 atm) or moderate (2.0 atm) fluid percussion (FP) …
Regional generation of leukotriene C4 after experimental brain injury in anesthetized rats
HS Dhillon, JM Dose, MR PRASAD - Journal of neurotrauma, 1996 - liebertpub.com
Regional concentrations of leukotriene C4 and extravasation of Evans blue were measured
after lateral fluid-percussion brain injury in rats. Tissue levels of LTC4 were elevated in the …
after lateral fluid-percussion brain injury in rats. Tissue levels of LTC4 were elevated in the …
Regional activities of phospholipase C after experimental brain injury in the rat
HS Dhillon, HM Carman, RM Prasad - Neurochemical research, 1999 - Springer
Regional activities of phosphoinositide-specific phospholipase C (PLC) were measured
after lateral fluid percussion (FP) brain injury in rats. The activity of PLC on …
after lateral fluid percussion (FP) brain injury in rats. The activity of PLC on …
Cyclic AMP-specific phosphodiesterase inhibitors
TJ Martins, KW Fowler, J Odingo, EA Kesicki… - US Patent …, 2002 - Google Patents
2001-06-25 Assigned to ICOS CORPORATION reassignment ICOS CORPORATION
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …
Regional expression of Bcl-2 mRNA and mitochondrial cytochrome c release after experimental brain injury in the rat
GX Dong, DK Singh, P Dendle, RM Prasad - Brain research, 2001 - Elsevier
Regional levels of anti-apoptotic Bcl-2 mRNA and the cytosolic cytochrome c protein were
measured after lateral fluid percussion (FP) brain injury in rats. Levels of Bcl-2 mRNA were …
measured after lateral fluid percussion (FP) brain injury in rats. Levels of Bcl-2 mRNA were …
Thiazole compounds as cyclic AMP-specific phosphodiesterase inhibitors and method of using the same
KW Fowler, J Odingo - US Patent 6,486,186, 2002 - Google Patents
Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of
making the same, are disclosed. Use of the compounds in the treatment of inflammatory …
making the same, are disclosed. Use of the compounds in the treatment of inflammatory …