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Recent updates on development of protein-tyrosine phosphatase 1B inhibitors for treatment of diabetes, obesity and related disorders
S Singh, AS Grewal, R Grover, N Sharma, B Chopra… - Bioorganic …, 2022 - Elsevier
The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …
[HTML][HTML] Computational methods in cooperation with experimental approaches to design protein tyrosine phosphatase 1B inhibitors in type 2 diabetes drug design: A …
MI Campos-Almazán, A Hernández-Campos… - Pharmaceuticals, 2022 - mdpi.com
Protein tyrosine phosphatase 1B (PTP1B) dephosphorylates phosphotyrosine residues and
is an important regulator of several signaling pathways, such as insulin, leptin, and the ErbB …
is an important regulator of several signaling pathways, such as insulin, leptin, and the ErbB …
Identification of natural products as selective PTP1B inhibitors via virtual screening
Y Yang, JY Tian, F Ye, Z **ao - Bioorganic Chemistry, 2020 - Elsevier
Protein tyrosine phosphatase 1B (PTP1B) is emerging as a promising yet challenging target
for drug discovery. To identify natural products as new prototypes for PTP1B inhibitors, we …
for drug discovery. To identify natural products as new prototypes for PTP1B inhibitors, we …
Advances in computer-aided drug design for type 2 diabetes
W Huang, L Zhang, Z Li - Expert Opinion on Drug Discovery, 2022 - Taylor & Francis
Introduction The number of diabetic patients is increasing, posing a heavy social and
economic burden worldwide. Traditional drug development technology is time-consuming …
economic burden worldwide. Traditional drug development technology is time-consuming …
Mining for Bioactive Molecules in Open Databases
G Macip, J Mestres‐Truyol… - … and Datasets for …, 2024 - Wiley Online Library
In this chapter we describe the main methods used during a virtual screening (ie ADMET
and PAINS filtering, protein–ligand docking, pharmacophore search, and shape/electrostatic …
and PAINS filtering, protein–ligand docking, pharmacophore search, and shape/electrostatic …