Aneurysmal subarachnoid hemorrhage is a devastating condition causing significant
morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in …

Delayed cerebral ischemia is a major predictor of poor outcomes in patients who suffer
subarachnoid hemorrhage. Treatment options are limited and often ineffective despite many …

During hemolysis, erythrophagocytes dispose damaged red blood cells. This prevents the
extracellular release of hemoglobin, detoxifies heme, and recycles iron in a linked metabolic …

Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …

In this mini-reflection, I explain how during my doctoral work in a Botany Department I first
became interested in H 2 O 2 and later in my career in other reactive oxygen species …

Aneurysmal subarachnoid hemorrhage (aSAH) is one of the most severe neurological
disorders, with a high mortality rate and severe disabling functional sequelae. Systemic …

Vascular diseases are multifactorial, often requiring multiple challenges, or 'hits', for their
initiation. Intra-vascular hemolysis illustrates well the multiple-hit theory where a first event …

Hemolysis and accumulation of cell-free hemoglobin (Hb) in the circulation or in confined
tissue compartments such as the subarachnoid space is an important driver of disease …

As the main particulate component of the circulating blood, RBCs play major roles in
physiological hemodynamics and impact all arterial wall pathologies. RBCs are the main …

Secondary brain injury after aneurysmal subarachnoid hemorrhage (SAH-SBI) contributes to
poor outcomes in patients after rupture of an intracranial aneurysm. The lack of diagnostic …