The role of tumor-associated macrophages in tumor immune evasion

R Huang, T Kang, S Chen - Journal of Cancer Research and Clinical …, 2024‏ - Springer
Background Tumor growth is closely linked to the activities of various cells in the tumor
microenvironment (TME), particularly immune cells. During tumor progression, circulating …

The role of different immunocompetent cell populations in the pathogenesis of head and neck cancer—regulatory mechanisms of pro-and anti-cancer activity and their …

K Starska-Kowarska - Cancers, 2023‏ - mdpi.com
Simple Summary According to the latest GLOBOCAN data, head and neck squamous cell
carcinoma (HNSCC) represents the sixth most prevalent human malignancy. Recent studies …

The role of tumor‐associated macrophages in hepatocellular carcinoma progression: A narrative review

X Zhang, C Yu, S Zhao, M Wang, L Shang… - Cancer …, 2023‏ - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world,
with complex etiology and mechanism, and a high mortality rate. Tumor‐associated …

USP7 inhibits the progression of nasopharyngeal carcinoma via promoting SPLUNC1-mediated M1 macrophage polarization through TRIM24

H Liu, L Tang, S Gong, T **ao, H Yang, W Gu… - Cell death & …, 2023‏ - nature.com
Reprogramming of macrophages toward an M1 phenotype is a novel strategy to induce
anticancer immunity. However, the regulatory mechanisms of M1 macrophage polarization …

The role of tumor-associated macrophages and soluble mediators in pulmonary metastatic melanoma

K **ong, M Qi, T Stoeger, J Zhang, S Chen - Frontiers in immunology, 2022‏ - frontiersin.org
Skin malignant melanoma is a highly aggressive skin tumor, which is also a major cause of
skin cancer-related mortality. It can spread from a relatively small primary tumor and …

Subtype-specific analysis of gene co-expression networks and immune cell profiling reveals high grade serous ovarian cancer subtype linkage to variable immune …

KM Carey, CD Young, AJ Clark, EB Dammer… - Journal of Ovarian …, 2024‏ - Springer
High-grade serous ovarian cancer (HGSOC) is marked by significant molecular diversity,
presenting a major clinical challenge due to its aggressive nature and poor prognosis. This …

Insights into IL-6/JAK/STAT3 Signaling in the Tumor Microenvironment: Implications for Cancer Therapy

WL Thuya, C Yang, PCL Ho, ALA Wong, L Wang… - Cytokine & Growth …, 2025‏ - Elsevier
Abstract The IL-6/JAK/STAT3 signaling pathway is a key regulator of tumor progression,
immune evasion, and therapy resistance in various cancers. Frequently dysregulated in …

HSP90 promotes tumor associated macrophage differentiation during triple-negative breast cancer progression

L Hong, M Tanaka, M Yasui, M Hara-Chikuma - Scientific reports, 2024‏ - nature.com
Tumor-associated macrophages (TAMs) originating from monocytes are crucial for cancer
progression; however, the mechanism of TAM differentiation is unclear. We investigated …

Recent advances in crosstalk between immune cells and cancer cells with ferroptosis

J Yi, W Zhang, Y Li, H Ren, Y **ang, C Qiao - Life Sciences, 2024‏ - Elsevier
Ferroptosis, a regulated form of cell death distinct from apoptosis and necrosis. Key
hallmarks include iron-dependent lipid peroxidation, glutathione depletion, and intracellular …

Quantitatively assessing the respiratory burst in innate immune cells

AL Sargent, JA Leedberg, JE Burress… - … : Methods and Protocols, 2023‏ - Springer
The respiratory burst is a rapid cellular consumption of oxygen resulting in abundant
production of reactive oxygen species (ROS), most often associated with primary mediators …