Conspectus Fluorescent probes have become powerful tools in biosensing and bioimaging
because of their high sensitivity, specificity, fast response, and technical simplicity. In the last …

Principle has it that even the most advanced super‐resolution microscope would be futile in
providing biological insight into subcellular matrices without well‐designed fluorescent …

Hypoxia, a quite universal feature in most solid tumors, has been considered as the
“Achilles' heel” of traditional photodynamic therapy (PDT) and substantially impairs the …

Nile red and Nile blue are highly fluorescent and photostable organic dyes from the benzo
[a] phenoxazine family. They have been used as histological stains for imaging lysosomes …

Given the wavelength dependence of tissue transparency and the requirement for
sufficiently low background autofluorescence, the development of fluorescent dyes with …

During autophagy, the intracellular components are captured in autophagosomes and
delivered to lysosomes for degradation and recycling. Changes in lysosomal trafficking and …

As one of the simplest reactive carbonyl species, formaldehyde is implicated in nervous
system diseases and cancer. Organelles play crucial roles in various physiological …

Molecular tools capable of providing information on a target analyte in an organelle of
interest are especially appreciated. Traditionally, organelle-targetable probes are designed …

Lysosomes are acidic organelles (approximately pH 4.5–5.5) and tracking the changes in
lysosomal pH is of great biological importance. To address this issue, quite a few of …

Three acidotropic, near-infrared fluorescent probes based on piperazine-modified BODIPY
dyes (A, B and C) have been developed for the sensitive and selective detection of …