Hepatitis C virus (HCV) remains a significant global health challenge. Approximately 50
million people were living with chronic hepatitis C based on the World Health Organization …

Hepatitis C virus (HCV) infection commonly causes progressive liver diseases that
deteriorate from chronic inflammation to fibrosis, cirrhosis and even to hepatocellular …

Drug repurposing is an important approach to the assignment of already approved drugs for
new indications. This technique bypasses some steps in the traditional drug approval …

Importance Hepatocellular carcinoma (HCC) is the leading oncologic cause of death among
patients with cirrhosis, but large studies examining mortality trends are lacking. Objective To …

The nicotinamide adenine dinucleotide phosphate hydrogen oxidase (NADPH oxidase or
NOX) plays a critical role in the inflammatory response and fibrosis in several organs such …

Abstract The World Health Organization estimates that 71 million people worldwide have
chronic hepatitis C viral infection. A major challenge is overall lack of public awareness of …

Background: Drug repurposing is the fastest effective method to provide treatment for
coronavirus disease (COVID-19). Drugs that targeting a closely related virus with similar …

Nowadays, exposure to infectious diseases caused by pathogenic viruses has become one
of the major human concerns in health fields. In the meantime, hepatitis viruses are …

Nucleotide and nucleoside-based analogue drugs are widely used for the treatment of both
acute and chronic viral infections. These drugs inhibit viral replication due to one or more …

Introduction With the introduction of highly effective and safe therapies with next-generation
direct-acting antivirals (DAAs), that act without interferon, hepatitis C virus (HCV) infection …