The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

The biogenic amine serotonin (5-hydroxytryptamine, 5-HT) plays a key role in regulating and
modulating various physiological and behavioral processes in both protostomes and …

The genetic basis of heart development is remarkably conserved from Drosophila to
mammals, and insights from flies have greatly informed our understanding of vertebrate …

The fruit fly Drosophila melanogaster has emerged as a useful model for cardiac diseases,
both developmental abnormalities and adult functional impairment. Using the tools of both …

The Drosophila larva has turned into a particularly simple model system for studying the
neuronal basis of innate behaviors and higher brain functions. Neuronal networks involved …

In Drosophila, one enzyme (Drosophila tryptophan‐phenylalanine hydroxylase, DTPHu)
hydroxylates both tryptophan to yield 5‐hydroxytryptophan, the first step in serotonin …

Abstract Serotonin (5-HT) regulates key processes in both vertebrates and invertebrates.
Previously, four 5-HT receptors that contributed to the 5-HT modulation of egg laying were …

Hematopoietic stem and progenitor cells maintain blood cell homeostasis by integrating
various cues provided by specialized microenvironments or niches. Biomechanical forces …

We present various methods to record cardiac function in the larval Drosophila. The
approaches allow heart rate to be measured in unrestrained and restrained whole larvae …

Drosophila serves as a playground for examining the effects of genetic mutations on
development, physiological function and behavior. Many physiological measures that …