The early years of alkyne metathesis were marked by a somewhat ironic state of affairs: the
proposed mechanism was swiftly validated and more than one effective catalyst became …

Natural products have had an immense influence on science and have directly led to the
introduction of many drugs. Organic chemistry, and its unique ability to tailor natural products …

Excising the nitrogen in secondary amines, and coupling the two residual fragments is a
skeletal editing strategy that can be used to construct molecules with new skeletons, but …

Chemical tools that enable a catalytic reaction to selectively and efficiently yield different
products will allow charting of wider chemical space. In ligand‐directed divergent synthesis …

Indole alkaloids bearing the tetracyclic indoline scaffolds of 1H‐pyrrolo [2, 3‐d] carbazole
have shown fascinating chemical diversity and significant biological activities. The …

Of the more than 100 casbane diterpenes known to date, only the eponymous parent
hydrocarbon casbene itself has ever been targeted by chemical synthesis. Outlined herein is …

An efficient entry into the phosphorylated marine macrolide enigmazole A is described.
Enigmazole A interferes with c‐Kit signaling by an as yet unknown mode of action and is …

Late‐stage modification is highly desirable for the diversification and modification of
biologically active compounds. Peripheral editing (eg, C− H activation) has been the …

Countless natural products of polyketide origin have an E‐configured 2‐methyl‐but‐2‐en‐1‐
ol substructure. An unconventional entry into this important motif was developed as part of a …

Lactimidomycin (1) was described in the literature as an exquisitely potent cell migration
inhibitor. Encouraged by this claim, we developed a concise and scalable synthesis of this …