Cancer genome-sequencing studies have revealed a remarkably high prevalence of
mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling complexes …

Features of the cancer epigenome distinguish cancers from their respective cell of origin and
establish therapeutic vulnerabilities that can be exploited through pharmacologic inhibition …

Breast cancers are complex cellular ecosystems where heterotypic interactions play central
roles in disease progression and response to therapy. However, our knowledge of their …

Clinical trials have identified ARID1A mutations as enriched among patients who respond
favorably to immune checkpoint blockade (ICB) in several solid tumor types independent of …

Cancer therapies that target epigenetic repressors can mediate their effects by activating
retroelements within the human genome. Retroelement transcripts can form double …

Abstract Background National Cancer Institute-Children's Oncology Group Pediatric
Molecular Analysis for Therapy Choice assigns patients aged 1-21 years with refractory …

Behçet's disease (BD) is a chronic vasculitis characterized by systemic immune aberrations.
However, a comprehensive understanding of immune disturbances in BD and how they …

Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and highly
aggressive ovarian malignancy. In almost all cases, it is associated with somatic and often …

Tumor-infiltrating lymphocytes (TILs), in general, and especially CD8+ TILs, represent a
favorable prognostic factor in non–small cell lung cancer (NSCLC). The tissue origin …

Our defenses against infection rely on the ability of the immune system to distinguish
invading pathogens from self. This task is exceptionally challenging, if not seemingly …