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Polymersome-based protein drug delivery–quo vadis?
Protein-based therapeutics are an attractive alternative to established therapeutic
approaches and represent one of the fastest growing families of drugs. While many of these …
approaches and represent one of the fastest growing families of drugs. While many of these …
pH‐responsive polymer nanoparticles for drug delivery
Stimuli‐responsive nanoparticles have the potential to improve the delivery of therapeutics
to a specific cell or region within the body. There are many stimuli that have shown potential …
to a specific cell or region within the body. There are many stimuli that have shown potential …
Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy
Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) are a promising
class of immunotherapeutics that activate innate immunity to increase tumour …
class of immunotherapeutics that activate innate immunity to increase tumour …
The endosomal escape of nanoparticles: toward more efficient cellular delivery
Many emerging therapies rely on the delivery of biological cargo into the cytosol.
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …
Proton-driven transformable nanovaccine for cancer immunotherapy
Cancer vaccines hold great promise for improved cancer treatment. However, endosomal
trap** and low immunogenicity of tumour antigens usually limit the efficiency of …
trap** and low immunogenicity of tumour antigens usually limit the efficiency of …
RAFT polymerization to form stimuli-responsive polymers
Stimuli-responsive polymers adapt to their surrounding environment. These polymers are
capable of responding to a variety of external stimuli, which include optical, electrical …
capable of responding to a variety of external stimuli, which include optical, electrical …
Nanotechnology platforms for cancer immunotherapy
Various cancer therapies have advanced remarkably over the past decade. Unlike the direct
therapeutic targeting of tumor cells, cancer immunotherapy is a new strategy that boosts the …
therapeutic targeting of tumor cells, cancer immunotherapy is a new strategy that boosts the …
pH-responsive hyaluronate-anchored extracellular vesicles to promote tumor-targeted drug delivery
Abstract pH-Responsive drug vehicles targeting the specific extracellular pH of tumors have
served as potent tools to overcome the limitation (eg., low tumor seletivity) in antitumor drug …
served as potent tools to overcome the limitation (eg., low tumor seletivity) in antitumor drug …
Poly (propylacrylic acid)-peptide nanoplexes as a platform for enhancing the immunogenicity of neoantigen cancer vaccines
Cancer vaccines targeting patient-specific tumor neoantigens have recently emerged as a
promising component of the rapidly expanding immunotherapeutic armamentarium …
promising component of the rapidly expanding immunotherapeutic armamentarium …
Controlling endosomal escape using nanoparticle composition: current progress and future perspectives
Polymer nanoparticles offer significant benefits for improving delivery of biological
therapeutics such as DNA and proteins, as they allow the cargo to be protected until it is …
therapeutics such as DNA and proteins, as they allow the cargo to be protected until it is …