Molecular diagnostic tools for the World Health Organization (WHO) 2021 classification of gliomas, glioneuronal and neuronal tumors; an EANO guideline

F Sahm, S Brandner, L Bertero, D Capper… - Neuro …, 2023‏ - academic.oup.com
In the 5th edition of the WHO CNS tumor classification (CNS5, 2021), multiple molecular
characteristics became essential diagnostic criteria for many additional CNS tumor types …

[HTML][HTML] Molecular pathology of tumors of the central nervous system

BW Kristensen, LP Priesterbach-Ackley, JK Petersen… - Annals of oncology, 2019‏ - Elsevier
Since the update of the 4th edition of the WHO Classification of Central Nervous System
(CNS) Tumors published in 2016, particular molecular characteristics are part of the …

Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients

JZ Wang, AP Landry, DR Raleigh, F Sahm… - Neuro …, 2024‏ - academic.oup.com
Meningiomas are the most common primary intracranial tumors in adults and are increasing
in incidence due to the aging population and increased access to neuroimaging. While most …

Molecular alterations in meningioma: prognostic and therapeutic perspectives

C Birzu, M Peyre, F Sahm - Current opinion in oncology, 2020‏ - journals.lww.com
The mutational landscape of meningioma has expanded following the use of the new
genetic sequencing approaches. Novel mutations have been characterized and reveal their …

CDKN2A/B deletions are strongly associated with meningioma progression: a meta-analysis of individual patient data

J Wach, AE Basaran, F Arlt, M Vychopen… - Acta Neuropathologica …, 2023‏ - Springer
Abstract Homozygous CDKN2A/B deletion has been associated with an increased risk of
recurrence in meningiomas. However, the evidence is confined to a limited number of …

Loss of H3K27me3 in meningiomas

F Nassiri, JZ Wang, O Singh, S Karimi… - Neuro …, 2021‏ - academic.oup.com
Background There is a critical need for objective and reliable biomarkers of outcome in
meningiomas beyond WHO classification. Loss of H3K27me3 has been reported as a …

SERPINH1 is a potential prognostic biomarker and correlated with immune infiltration: a pan-cancer analysis

Y Wang, W Gu, W Wen, X Zhang - Frontiers in genetics, 2022‏ - frontiersin.org
Background: Serpin peptidase inhibitor clade H, member 1 (SERPINH1) is a gene encoding
a member of the serpin superfamily of serine proteinase inhibitors. The upregulated of …

[HTML][HTML] Molecular characteristics of meningiomas

YS Lee, YS Lee - Journal of pathology and translational …, 2020‏ - synapse.koreamed.org
Meningioma is the most common primary intracranial tumor in adults. The grading of
meningioma is based on World Health Organization criteria, which rely on histopathological …

Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas

JZ Wang, V Patil, J Liu, H Dogan, G Tabatabai… - Acta …, 2023‏ - Springer
Homozygous deletion of CDKN2A/B was recently incorporated into the World Health
Organization classification for grade 3 meningiomas. While this marker is overall rare in …

Dose-escalated radiation therapy is associated with improved outcomes for high-grade meningioma

KL Zeng, H Soliman, S Myrehaug, CL Tseng… - International Journal of …, 2024‏ - Elsevier
Purpose The optimal modern radiation therapy (RT) approach after surgery for atypical and
malignant meningioma is unclear. We present results of dose escalation in a single …