Purpose Although doxorubicin chemotherapy is commonly applied for treating different
malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical …

Endothelial cells are located at the crucial interface between circulating blood and semi-
solid tissues and have many important roles in maintaining systemic physiological function …

Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …

The dose-dependent toxicity to cardiomyocytes has been well recognized as a central
characteristic of doxorubicin (DOX)-induced cardiotoxicity (DIC), however, the pathogenesis …

Objectives: Identify the indications for using doxorubicin in a chemotherapeutic regimen.
Summarize the mechanism of action of doxorubicin. Review the adverse event profile and …

In western countries, cardiovascular (CV) disease and cancer are the leading causes of
death in the ageing population. Recent epidemiological data suggest that cancer is more …

In the present study, we explored SA's activity against DOX‐induced cardiotoxicity and
revealed its underlying mechanisms. Male Wistar rats (weight, 190‐210g; n= 6) were …

Purpose Doxorubicin, as an effective chemotherapeutic drug, is commonly used for
combating various solid and hematological tumors. However, doxorubicin-induced …

Cardiotoxicity is a major side effect of the chemotherapeutic drug doxorubicin (Dox), which is
further exacerbated when it is combined with trastuzumab, a standard care approach for …

Aims The aim of this study was to study changes in coronary microcirculation status during
and after several cycles of anthracycline treatment. Methods and results Large-white male …