Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …

Ageing is intimately connected to the induction of cell senescence,, but why this is so
remains poorly understood. A key challenge is the identification of pathways that normally …

Cancer-associated fibroblasts (CAFs) are prominent components of the microenvironment in
most types of solid tumors, and were shown to facilitate cancer progression by supporting …

Increased immune cell infiltration into tumors is associated with improved patient survival
and predicts response to immune therapies. Thus, identification of factors that determine the …

Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation
of secondary tumors. This process is complex and is spatially and temporally regulated by …

Abstract Background Cancer-associated fibroblasts (CAFs) are the most principal cells of
depositing and remodeling extracellular matrix (ECM) within solid tumours. Both CAFs and …

Simple Summary In this perspective article we discuss the importance of investigating the
role of the ECM on tumor metastasis and tumor dormancy. First, we discuss the importance …

Melanoma is a deadly skin cancer that becomes especially difficult to treat after it
metastasizes. Timely identification of melanoma is critical for effective therapy, but …

MacroH2A has established tumour suppressive functions in melanoma and other cancers,
but an unappreciated role in the tumour microenvironment. Using an autochthonous …