The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …

Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

Abstract Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a
simple protocol for detection of open chromatin. Computational footprinting, the search for …

Rapid perturbation of protein function permits the ability to define primary molecular
responses while avoiding downstream cumulative effects of protein dysregulation. The auxin …

ChIP-seq and ChIP-exo identify where proteins bind along any genome in vivo. Although
ChIP-seq is widely adopted in academic research, it has inherently high noise. In contrast …

Background Chromatin dysregulation is associated with developmental disorders and
cancer. Numerous methods for measuring genome-wide chromatin accessibility have been …

ATAC-seq has been widely adopted to identify accessible chromatin regions across the
genome. However, current data analysis still utilizes approaches initially designed for ChIP …

Background DNase-seq and ATAC-seq are broadly used methods to assay open chromatin
regions genome-wide. The single nucleotide resolution of DNase-seq has been further …

Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has
identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T …

The access of Transcription Factors (TFs) to their cognate DNA binding motifs requires a
precise control over nucleosome positioning. This is especially important following DNA …