[HTML][HTML] Viral hepatitis update: Progress and perspectives

MB Pisano, CG Giadans, DM Flichman… - World journal of …, 2021 - ncbi.nlm.nih.gov
Viral hepatitis, secondary to infection with hepatitis A, B, C, D, and E viruses, are a major
public health problem and an important cause of morbidity and mortality. Despite the huge …

Hepatocellular carcinoma mechanisms associated with chronic HCV infection and the impact of direct-acting antiviral treatment

S Dash, Y Aydin, KE Widmer… - Journal of hepatocellular …, 2020 - Taylor & Francis
Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …

[HTML][HTML] Cancer-associated fibroblasts provide a stromal niche for liver cancer organoids that confers trophic effects and therapy resistance

J Liu, P Li, L Wang, M Li, Z Ge, L Noordam… - Cellular and molecular …, 2021 - Elsevier
Background & Aims Cancer-associated fibroblasts (CAFs) play a key role in the cancer
process, but the research progress is hampered by the paucity of preclinical models that are …

Hepatitis C virus leaves an epigenetic signature post cure of infection by direct-acting antivirals

S Perez, A Kaspi, T Domovitz, A Davidovich… - PLoS …, 2019 - journals.plos.org
The increasing worldwide prevalence of Hepatocellular carcinoma (HCC), characterized by
resistance to conventional chemotherapy, poor prognosis and eventually mortality, place it …

The impact of treatment of hepatitis C with DAA s on the occurrence of HCC

B Roche, A Coilly, JC Duclos‐Vallee… - Liver …, 2018 - Wiley Online Library
Hepatitis C virus infection is a major cause of chronic hepatitis resulting in cirrhosis and
hepatocellular carcinoma (HCC). The recent introduction of direct acting antivirals (DAA) …

Updating the clinical application of blood biomarkers and their algorithms in the diagnosis and surveillance of hepatocellular carcinoma: a critical review

E Shahini, G Pasculli, AG Solimando, C Tiribelli… - International Journal of …, 2023 - mdpi.com
The most common primary liver cancer is hepatocellular carcinoma (HCC), and its mortality
rate is increasing globally. The overall 5-year survival of patients with liver cancer is …

Serum biomarkers for the prediction of hepatocellular carcinoma

JD Debes, PA Romagnoli, J Prieto, M Arrese… - Cancers, 2021 - mdpi.com
Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Major etiologies
of HCC relate to chronic viral infections as well as metabolic conditions. The survival rate of …

Risk of hepatocellular carcinoma after HCV clearance by direct-acting antivirals treatment predictive factors and role of epigenetics

L Rinaldi, R Nevola, G Franci, A Perrella, G Corvino… - Cancers, 2020 - mdpi.com
Direct-acting antivirals (DAAs) induce a rapid virologic response (SVR) in up to 99% of
chronic hepatitis C patients. The role of SVR by DAAs on the incidence or recurrence of …

The role of cytokines in the different stages of hepatocellular carcinoma

N Rico Montanari, CM Anugwom, A Boonstra… - Cancers, 2021 - mdpi.com
Simple Summary Non-homeostatic cytokine expression during hepatocellular
carcinogenesis, together with simple and inexpensive cytokine detection techniques, has …

Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation

AA Negash, RM Olson, S Griffin, M Gale Jr - PLoS Pathogens, 2019 - journals.plos.org
Hepatitis C virus (HCV) infection remains a major cause of hepatic inflammation and liver
disease. HCV triggers NLRP3 inflammasome activation and interleukin-1β (IL-1β) …