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Multicomponent reaction toolbox for peptide macrocyclization and stapling
In the past decade, multicomponent reactions have experienced a renaissance as powerful
peptide macrocyclization tools enabling the rapid creation of skeletal complexity and …
peptide macrocyclization tools enabling the rapid creation of skeletal complexity and …
[HTML][HTML] Macrocyclization reactions: The importance of conformational, configurational, and template-induced preorganization
V Marti-Centelles, MD Pandey, MI Burguete… - Chemical …, 2015 - ACS Publications
Macrocyclic structures are common synthetic targets in drug discovery,(1, 2) and therefore,
interest in their study is continuously increasing in this field.(3, 4) A classic example is …
interest in their study is continuously increasing in this field.(3, 4) A classic example is …
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery
Macrocycles occupy a unique segment of chemical space. In the past decade, their chemical
diversity expanded significantly, supported by advances in bioinformatics and synthetic …
diversity expanded significantly, supported by advances in bioinformatics and synthetic …
Peptoid polymers: a highly designable bioinspired material
J Sun, RN Zuckermann - ACS nano, 2013 - ACS Publications
Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …
advantages over their natural counterparts: the ability to precisely tune their structures over a …
Supramolecular and molecular capsules, cages and containers
CJT Cox, J Hale, P Molinska, JEM Lewis - Chemical Society Reviews, 2024 - pubs.rsc.org
Stemming from early seminal notions of molecular recognition and encapsulation, three-
dimensional, cavity-containing capsular compounds and assemblies have attracted intense …
dimensional, cavity-containing capsular compounds and assemblies have attracted intense …
Emergence of hemicryptophanes: from synthesis to applications for recognition, molecular machines, and supramolecular catalysis
D Zhang, A Martinez, JP Dutasta - Chemical reviews, 2017 - ACS Publications
In the wide area of host–guest chemistry, hemicryptophanes, combining a cyclotribenzylene
(or cyclotriveratrylene CTV) unit with another different C 3-symmetrical moiety, appears as a …
(or cyclotriveratrylene CTV) unit with another different C 3-symmetrical moiety, appears as a …
Molecular vessels from preorganised natural building blocks
Supramolecular vessels emerged as tools to mimic and better understand
compartmentalisation, a central aspect of living matter. However, many more applications …
compartmentalisation, a central aspect of living matter. However, many more applications …
Multiple multicomponent macrocyclizations (MiBs): a strategic development toward macrocycle diversity
Macrocycles are of high significance in areas as diverse as drug development and
supramolecular chemistry. They can be considered as privileged molecules because they …
supramolecular chemistry. They can be considered as privileged molecules because they …
Thiol-Yne click chemistry of acetylene-enabled macrocyclization
S Lü, Z Wang, S Zhu - Nature Communications, 2022 - nature.com
Macrocycles have fascinated scientists for over half a century due to their aesthetically
appealing structures and broad utilities in chemical, material, and biological research …
appealing structures and broad utilities in chemical, material, and biological research …
Construction of stable porous organic cages: from the perspective of chemical bonds
Porous organic cages (POCs) are constructed from purely organic synthons by covalent
linkages with intrinsic cavities and have shown potential applications in many areas …
linkages with intrinsic cavities and have shown potential applications in many areas …