Multicomponent reaction toolbox for peptide macrocyclization and stapling

L Reguera, DG Rivera - Chemical reviews, 2019 - ACS Publications
In the past decade, multicomponent reactions have experienced a renaissance as powerful
peptide macrocyclization tools enabling the rapid creation of skeletal complexity and …

[HTML][HTML] Macrocyclization reactions: The importance of conformational, configurational, and template-induced preorganization

V Marti-Centelles, MD Pandey, MI Burguete… - Chemical …, 2015 - ACS Publications
Macrocyclic structures are common synthetic targets in drug discovery,(1, 2) and therefore,
interest in their study is continuously increasing in this field.(3, 4) A classic example is …

Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery

E Marsault, ML Peterson - Journal of medicinal chemistry, 2011 - ACS Publications
Macrocycles occupy a unique segment of chemical space. In the past decade, their chemical
diversity expanded significantly, supported by advances in bioinformatics and synthetic …

Peptoid polymers: a highly designable bioinspired material

J Sun, RN Zuckermann - ACS nano, 2013 - ACS Publications
Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

Supramolecular and molecular capsules, cages and containers

CJT Cox, J Hale, P Molinska, JEM Lewis - Chemical Society Reviews, 2024 - pubs.rsc.org
Stemming from early seminal notions of molecular recognition and encapsulation, three-
dimensional, cavity-containing capsular compounds and assemblies have attracted intense …

Emergence of hemicryptophanes: from synthesis to applications for recognition, molecular machines, and supramolecular catalysis

D Zhang, A Martinez, JP Dutasta - Chemical reviews, 2017 - ACS Publications
In the wide area of host–guest chemistry, hemicryptophanes, combining a cyclotribenzylene
(or cyclotriveratrylene CTV) unit with another different C 3-symmetrical moiety, appears as a …

Molecular vessels from preorganised natural building blocks

A Llamosí, MP Szymański, A Szumna - Chemical Society Reviews, 2024 - pubs.rsc.org
Supramolecular vessels emerged as tools to mimic and better understand
compartmentalisation, a central aspect of living matter. However, many more applications …

Multiple multicomponent macrocyclizations (MiBs): a strategic development toward macrocycle diversity

LA Wessjohann, DG Rivera, OE Vercillo - Chemical reviews, 2009 - ACS Publications
Macrocycles are of high significance in areas as diverse as drug development and
supramolecular chemistry. They can be considered as privileged molecules because they …

Thiol-Yne click chemistry of acetylene-enabled macrocyclization

S Lü, Z Wang, S Zhu - Nature Communications, 2022 - nature.com
Macrocycles have fascinated scientists for over half a century due to their aesthetically
appealing structures and broad utilities in chemical, material, and biological research …

Construction of stable porous organic cages: from the perspective of chemical bonds

M Yang, K Su, D Yuan - Chemical Communications, 2024 - pubs.rsc.org
Porous organic cages (POCs) are constructed from purely organic synthons by covalent
linkages with intrinsic cavities and have shown potential applications in many areas …