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Applications of focused ultrasound in the brain: from thermoablation to drug delivery
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …
clinic represents the culmination of decades of research. Lying at the convergence of …
The blood-brain barrier: Physiology and strategies for drug delivery
The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …
reflecting the unique requirements of the brain. In this review, following a brief historical …
Applications of focused ultrasound-mediated blood-brain barrier opening
The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
[HTML][HTML] Ultrasound-responsive cavitation nuclei for therapy and drug delivery
Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for
beneficial tissue bio-effects are actively under development. The mechanical oscillations of …
beneficial tissue bio-effects are actively under development. The mechanical oscillations of …
Clinical trial of blood-brain barrier disruption by pulsed ultrasound
The blood-brain barrier (BBB) limits the delivery of systemically administered drugs to the
brain. Methods to circumvent the BBB have been developed, but none are used in standard …
brain. Methods to circumvent the BBB have been developed, but none are used in standard …
Ultrasound as a versatile tool for short-and long-term improvement and monitoring of brain function
Treating the brain with focused ultrasound (FUS) at low intensities elicits diverse responses
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …
Noninvasive hippocampal blood− brain barrier opening in Alzheimer's disease with focused ultrasound
The blood–brain barrier (BBB) presents a significant challenge for treating brain disorders.
The hippocampus is a key target for novel therapeutics, playing an important role in …
The hippocampus is a key target for novel therapeutics, playing an important role in …
Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation
ZI Kovacs, S Kim, N Jikaria, F Qureshi, B Milo… - Proceedings of the …, 2017 - pnas.org
MRI-guided pulsed focused ultrasound (pFUS) combined with systemic infusion of
ultrasound contrast agent microbubbles (MB) causes localized blood–brain barrier (BBB) …
ultrasound contrast agent microbubbles (MB) causes localized blood–brain barrier (BBB) …
Localized blood–brain barrier opening in infiltrating gliomas with MRI-guided acoustic emissions–controlled focused ultrasound
Pharmacological treatment of gliomas and other brain-infiltrating tumors remains
challenging due to limited delivery of most therapeutics across the blood–brain barrier …
challenging due to limited delivery of most therapeutics across the blood–brain barrier …
Focused ultrasound–mediated blood-brain barrier opening in Alzheimer's disease: long-term safety, imaging, and cognitive outcomes
OBJECTIVE MRI-guided low-intensity focused ultrasound (FUS) has been shown to
reversibly open the blood-brain barrier (BBB), with the potential to deliver therapeutic agents …
reversibly open the blood-brain barrier (BBB), with the potential to deliver therapeutic agents …