Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Chagas disease, caused by the infection with T rypanosoma cruzi, is endemic in all L atin A
merica. Due to the increase in population migration, C hagas disease has spread worldwide …

Chagas disease (CD), caused by Trypanosoma cruzi (T. cruzi) protozoa, is a complicated
parasitic illness with inadequate medical measures for diagnosing infection and monitoring …

Monocytes are classified according to their CD14 and CD16 expression into classical
(reparative), intermediate (inflammatory), and non-classical. This study assessed the …

Trypanosoma cruzi is the etiologic agent of Chagas' disease, which affects 6–7 million
people worldwide. Different strains of T. cruzi present specific genotypic and phenotypic …

Chagas disease cardiomyopathy (CCC), the main consequence of Trypanosoma cruzi (T.
cruzi) infection, is an inflammatory cardiomyopathy that develops in up to 30% of infected …

Many pathogenic organisms need to reach either an intracellular compartment or the
cytoplasm of a target cell for their survival, replication or immune system evasion …

Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. This illness is now becoming global, mainly due to congenital …

Recombinant protein vaccines are safe but elicit low immunological responses. The new
generation of adjuvants is currently reversing this situation. Here, a new antigen–adjuvant …

Abstract Background Infection with Trypanosoma cruzi, the protozoan parasite that causes
Chagas disease, results in chronic infection that leads to cardiomyopathy with increased …