Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-
alcoholic fatty liver disease, is characterized by hepatic steatosis and metabolic dysfunction …

Aging is a complex biological process characterized by a progressive decline in cellular and
tissue function, ultimately leading to organismal aging. Stem cells, with their regenerative …

The constant increase in the elderly population presents significant challenges in
addressing new social, economic, and health problems concerning this population. With …

Spermidine exerts protective roles in obesity, while the mechanism of spermidine in adipose
tissue thermogenesis remains unclear. The present study first investigated the effect of …

Mitochondrial dysfunction has been widely implicated in the pathogenesis of Alzheimer's
disease (AD), with accumulation of damaged and dysfunctional mitochondria occurring early …

Alzheimer's disease is the most prevalent neurodegenerative disorder and affects the lives
not only of those who are diagnosed but also of their caregivers. Despite the enormous …

Introduction: Mitophagy, the selective degradation of damaged mitochondria, is essential for
maintaining cellular health and function, particularly in high-energy demanding post-mitotic …

A substantial challenge in human brain aging is to find a suitable model to mimic neuronal
aging in vitro as accurately as possible. Using directly converted neurons (iNs) from human …

The accumulation of damaged mitochondria has long been considered a hallmark of the
aging process. Among various factors, age-related mitochondrial alterations comprise …

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder and the leading cause
of age-related cognitive decline. Recent studies have established a close relationship …