Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities
The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
[HTML][HTML] Small heat shock proteins: role in cellular functions and pathology
Small heat shock proteins (sHsps) are conserved across species and are important in stress
tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target …
tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target …
Modulation of cardiac contractility by the phopholamban/SERCA2a regulatome
EG Kranias, RJ Hajjar - Circulation research, 2012 - Am Heart Assoc
Heart disease remains the leading cause of death and disability in the Western world.
Current therapies aim at treating the symptoms rather than the subcellular mechanisms …
Current therapies aim at treating the symptoms rather than the subcellular mechanisms …
MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20
Background—Recent studies have identified critical roles for microRNAs (miRNAs) in a
variety of cellular processes, including regulation of cardiomyocyte death. However, the …
variety of cellular processes, including regulation of cardiomyocyte death. However, the …
Heat shock proteins in oxidative stress and ischemia/reperfusion injury and benefits from physical exercises: a review to the current knowledge
Heat shock proteins (HSPs) are molecular chaperones produced in response to oxidative
stress (OS). These proteins are involved in the folding of newly synthesized proteins and …
stress (OS). These proteins are involved in the folding of newly synthesized proteins and …
Large potentials of small heat shock proteins
Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …
is presented, and the structure and properties of three members of this family are analyzed …
Hsp20-mediated activation of exosome biogenesis in cardiomyocytes improves cardiac function and angiogenesis in diabetic mice
Decreased heat shock protein (Hsp) expression in type 1 and type 2 diabetes has been
implicated as a primary factor contributing to diabetes-induced organ damage. We recently …
implicated as a primary factor contributing to diabetes-induced organ damage. We recently …
The innate immune response in reperfused myocardium
L Timmers, G Pasterkamp, VC de Hoog… - Cardiovascular …, 2012 - academic.oup.com
One of the major therapeutic challenges in the arena of interventional cardiology is to design
strategies aimed at reducing myocardial tissue damage after myocardial infarction. In …
strategies aimed at reducing myocardial tissue damage after myocardial infarction. In …
Stress biomarkers and proteomics alteration to thermal stress in ruminants: A review
Heat stress may adversely affect physiochemical and immune responses of livestock and
alter biological functions. The comfort or thermoneutral zone for livestock, which has long …
alter biological functions. The comfort or thermoneutral zone for livestock, which has long …
MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury
Background—MicroRNAs (miRs) participate in many cardiac pathophysiological processes,
including ischemia/reperfusion (I/R)-induced cardiac injury. Recently, we and others …
including ischemia/reperfusion (I/R)-induced cardiac injury. Recently, we and others …