RNA structural dynamics as captured by molecular simulations: a comprehensive overview
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
Fundamental studies of functional nucleic acids: aptamers, riboswitches, ribozymes and DNAzymes
This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …
Rational evolution of Cd2+-specific DNAzymes with phosphorothioate modified cleavage junction and Cd2+ sensing
In vitro selection of RNA-cleaving DNAzymes is a powerful method for isolating metal-
specific DNA. A few successful examples are known, but it is still difficult to target some …
specific DNA. A few successful examples are known, but it is still difficult to target some …
An Ultrasensitive Light-up Cu2+ Biosensor Using a New DNAzyme Cleaving a Phosphorothioate-Modified Substrate
Cu2+ is a very important metal ion in biology, environmental science, and industry.
Develo** biosensors for Cu2+ is a key topic in analytical chemistry. DNAzyme-based …
Develo** biosensors for Cu2+ is a key topic in analytical chemistry. DNAzyme-based …
Force Field for Mg2+, Mn2+, Zn2+, and Cd2+ Ions That Have Balanced Interactions with Nucleic Acids
MT Panteva, GM Giambasu… - The Journal of Physical …, 2015 - ACS Publications
Divalent metal ions are of fundamental importance to the function and folding of nucleic
acids. Divalent metal ion–nucleic acid interactions are complex in nature and include both …
acids. Divalent metal ion–nucleic acid interactions are complex in nature and include both …
Phosphorothioate nucleic acids for probing metal binding, biosensing and nanotechnology
Phosphorothioate (PS) modification replaces one of the non-bridging oxygen atoms by
sulfur in the phosphate backbone of nucleic acids. While PS DNAs have been traditionally …
sulfur in the phosphate backbone of nucleic acids. While PS DNAs have been traditionally …
In vitro selection of chemically modified DNAzymes
DNAzymes are in vitro selected DNA oligonucleotides with catalytic activities. RNA cleavage
is one of the most extensively studied DNAzyme reactions. To expand the chemical …
is one of the most extensively studied DNAzyme reactions. To expand the chemical …
Unveiling the sulfur–sulfur bridge: Accurate structural and energetic characterization of a homochalcogen intermolecular bond
By combining rotational spectroscopy in supersonic expansion with the capability of state‐of‐
the‐art quantum‐chemical computations in accurately determining structural and energetic …
the‐art quantum‐chemical computations in accurately determining structural and energetic …
Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme
DNAzymes (deoxyribozymes) are single-stranded DNA molecules endowed with catalytic
activity, obtained by in vitro selection. In the past 25 years, dozens of DNAzymes have been …
activity, obtained by in vitro selection. In the past 25 years, dozens of DNAzymes have been …
A new heavy lanthanide-dependent DNAzyme displaying strong metal cooperativity and unrescuable phosphorothioate effect
In vitro selection of RNA-cleaving DNAzymes was performed using three heavy lanthanide
ions (Ln3+): Ho3+, Er3+ and Tm3+. The resulting sequences were aligned together and …
ions (Ln3+): Ho3+, Er3+ and Tm3+. The resulting sequences were aligned together and …