The shape and form of protozoan parasites are inextricably linked to their pathogenicity. The
evolutionary pressure associated with establishing and maintaining an infection and …

TrypTag is a major resource which will contain the localisation of every protein encoded in
the Trypanosoma brucei genome. Localisations of over 2000 proteins are already available …

Gene exchange between viruses and their hosts acts as a key facilitator of horizontal gene
transfer and is hypothesized to be a major driver of evolutionary change. Our understanding …

Trypanosoma brucei is a model trypanosomatid, an important group of human, animal and
plant unicellular parasites. Understanding their complex cell architecture and life cycle is …

Leishmania are eukaryotic parasites that have retained the ability to produce extracellular
vesicles (EVs) through evolution. To date, it has been unclear if different DNA entities could …

The correct interpretation of any phylogenetic tree is dependent on that tree being correctly
rooted. We present STRIDE, a fast, effective, and outgroup-free method for identification of …

Spermatogenesis defects concern millions of men worldwide, yet the vast majority remains
undiagnosed. Here we report men with primary infertility due to multiple morphological …

Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS)
diversity set of 1.8 million compounds was screened against the three kinetoplastids most …

Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted
by infected sand flies. Vaccination through leishmanization with live Leishmania major has …

Background: Modern chemical toxicology is facing a growing need to Reduce, Refine, and
Replace animal tests for hazard identification. The most common type of animal assays for …