Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Canonical activation of the inflammasome is critical to promote caspase-1-dependent
maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to induce pyroptotic …

Microbial infections are recognized by the innate immune system both to elicit immediate
defense and to generate long-lasting adaptive immunity. To detect and respond to vastly …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Recent studies have offered a glimpse into the sophisticated mechanisms by which
inflammasomes respond to danger and promote secretion of interleukin (IL)-1β and IL-18 …

Inflammatory and apoptotic caspases are central players in inflammation and apoptosis,
respectively. However, recent studies have revealed that these caspases have functions …

Lipopolysaccharide from Gram-negative bacteria is sensed in the host cell cytoplasm by a
non-canonical inflammasome pathway that ultimately results in caspase-11 activation and …

Inflammasomes are cytosolic multiprotein platforms assembled in response to invading
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …

Inflammatory responses mediated by macrophages are part of the innate immune system,
whose role is to protect against invading pathogens. Lipopolysaccharide (LPS) found in the …

A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat
containing, or NOD-like receptor) proteins is in inflammasome activation, which has been …