Biomedical polymers: synthesis, properties, and applications
Biomedical polymers have been extensively developed for promising applications in a lot of
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …
Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids
Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …
Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration
Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application
Synthetic polypeptides from the ring-opening polymerization of N-carboxyanhydrides
(NCAs) are one of the most important biomaterials. The unique features of these synthetic …
(NCAs) are one of the most important biomaterials. The unique features of these synthetic …
Smart chemistry-based nanosized drug delivery systems for systemic applications: a comprehensive review
This review focuses on the smart chemistry that has been utilized in develo** polymer-
based drug delivery systems over the past 10 years. We provide a comprehensive overview …
based drug delivery systems over the past 10 years. We provide a comprehensive overview …
Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide
Effective and safe delivery of the CRISPR/Cas9 gene-editing elements remains a challenge.
Here we report the development of PEGylated nanoparticles (named P-HNPs) based on the …
Here we report the development of PEGylated nanoparticles (named P-HNPs) based on the …
Polymeric nanostructured materials for biomedical applications
Polymeric nanostructured materials (PNMs), which are polymeric materials in nanoscale or
polymer composites containing nanomaterials, have become increasingly useful for …
polymer composites containing nanomaterials, have become increasingly useful for …
Oral nanotherapeutics based on Antheraea pernyi silk fibroin for synergistic treatment of ulcerative colitis
Ulcerative colitis (UC) with its rapidly increasing incidence has become an emerging
challenge for public health. Therapeutic agents are required to be specifically delivered to …
challenge for public health. Therapeutic agents are required to be specifically delivered to …
A reactive oxygen species (ROS)-responsive polymer for safe, efficient, and targeted gene delivery in cancer cells
The high intracellular oxidative stress in a cancer cell is a biologically relevant stimulus for
efficient intracellular delivery of therapeutic genes. In this study, reactive oxygen species …
efficient intracellular delivery of therapeutic genes. In this study, reactive oxygen species …
In vitro selection of a sodium-specific DNAzyme and its application in intracellular sensing
Over the past two decades, enormous progress has been made in designing fluorescent
sensors or probes for divalent metal ions. In contrast, the development of fluorescent …
sensors or probes for divalent metal ions. In contrast, the development of fluorescent …