In recent years, the biological role of changes in physical factors in carcinogenesis and
progression has attracted increasing attention. Matrix stiffness, also known as ECM stress, is …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

The mechanical properties of cells and tissues help determine their architecture,
composition and function. Alterations to these properties are associated with many diseases …

Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

Ultrasound-responsive agents have shown great potential as targeted drug delivery agents,
effectively augmenting cell permeability and facilitating drug absorption. This review focuses …

Control of the structure and function of three-dimensional multicellular tissues depends
critically on the spatial and temporal coordination of cellular physical properties, yet the …

In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This
structural plasticity, which facilitates their migration and communicative function, also …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

The physical characteristics of tumours are intricately linked to the tumour phenotype and
difficulties during treatment. Many factors contribute to the increased stiffness of tumours; …