Recent advances in the understanding of enterovirus A71 infection: a focus on neuropathogenesis

HK Tee, MI Zainol, IC Sam, YF Chan - Expert Review of Anti …, 2021 - Taylor & Francis
Introduction: Hand, foot, and mouth disease caused by enterovirus A71 (EV-A71) is more
frequently associated with neurological complications and deaths compared to other …

[HTML][HTML] From the “One-Molecule, One-Target, One-Disease” Concept towards Looking for Multi-Target Therapeutics for Treating Non-Polio Enterovirus (NPEV) …

H Roux, F Touret, P Rathelot, P Vanelle… - …, 2024 - pmc.ncbi.nlm.nih.gov
Non-polio enteroviruses (NPEVs), namely coxsackieviruses (CV), echoviruses (E),
enteroviruses (EV), and rhinoviruses (RV), are responsible for a wide variety of illnesses …

Design of 4-Substituted Sulfonamidobenzoic Acid Derivatives Targeting Coxsackievirus B3

AA Shetnev, AS Volobueva, VA Panova, VV Zarubaev… - Life, 2022 - mdpi.com
A series of novel 4-substituted sulfonamidobenzoic acid derivatives was synthesized as the
structural evolution of 4-(4-(1, 3-dioxoisoindolin-2-yl) phenylsulfonamido) benzoic acid …

[HTML][HTML] Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71

M Salerno, C Varricchio, F Bevilacqua… - European Journal of …, 2023 - Elsevier
Different viruses belonging to distinct viral families, such as enterovirus 71, rely on the host
methyltransferase METTL3 for the completion of fundamental cytoplasmic stages of their life …

The multiple roles of viral 3Dpol protein in picornavirus infections

Z Nie, F Zhai, H Zhang, H Zheng, J Pei - Virulence, 2024 - Taylor & Francis
The Picornaviridae are a large group of positive-sense, single-stranded RNA viruses, and
most research has focused on the Enterovirus genus, given they present a severe health risk …

Differential inhibition of intra-and inter-molecular protease cleavages by antiviral compounds

JS Doherty, K Kirkegaard - Journal of Virology, 2023 - Am Soc Microbiol
Enteroviruses encode two protease active sites, in the 2A and 3C coding regions. While they
target many host proteins, they first need to be excised from the viral polyprotein in which …

Insights into enterovirus a-71 antiviral development: from natural sources to synthetic nanoparticles

S Feferbaum-Leite, IA Santos, VR Grosche… - Archives of …, 2023 - Springer
Enteroviruses are pathogens responsible for several diseases, being enterovirus A71
(EVA71) the second leading cause of hand, foot, and mouth disease (HFMD), especially in …

Emerging Therapeutics in the Fight Against EV‐D68: A Review of Current Strategies

N Kalam… - Influenza and Other …, 2024 - Wiley Online Library
ABSTRACT Enterovirus‐D68 (EV‐D68) was first identified in 1962 in pediatric patients with
acute respiratory conditions in California, USA (US). From the 1970s to 2005, EV‐D68 was …

MK-0608 inhibits in vitro and in vivo RNA replication of infectious pancreatic necrosis virus

L Li, J Zhao, Y Shao, J Ma, T Lu, L Xu - Fish & Shellfish Immunology, 2024 - Elsevier
Infectious pancreatic necrosis virus (IPNV) is an important pathogen that is threatening the
worldwide salmon and trout industry. But there is no therapeutic drug available for now. In …

Recent advances in anti-coxsackievirus A16 viral drug research

X Yuan, Z Liu, L Wan, W Liu, Y Huang… - Future Medicinal …, 2023 - Taylor & Francis
Hand, foot and mouth disease, a childhood disorder caused by enteroviruses, is
intermittently endemic in the Asia-Pacific region and endangers the lives of many infants and …