The resurgence of tuberculosis worldwide has intensified research efforts directed at
examining the host defense and pathogenic mechanisms operative in Mycobacterium …

Tuberculosis (TB), an illness that mainly affects the respiratory system, is one of the world's
most pernicious diseases. TB currently infects one-third of the world's population and kills …

Mycobacterium tuberculosis represents a world-wide health risk and immunosuppression is
a particular problem in M. tuberculosis infections. Although macrophages are primarily …

For intracellular pathogens such as Salmonellae, Mycobacteriae and Brucellae, infection
requires adaptation to the intracellular environment of the phagocytic cell. The transition …

Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has
plagued humans for thousands of years. TB still remains a major public health problem in …

The resurgence of concern about tuberculosis has resulted in the discovery that
Mycobacterium tuberculosis, a facultative intracellular pathogen, has developed numerous …

The tubercle bacillus parasitizes macrophages by inhibiting phagosome maturation into the
phagolysosome. This phenomenon underlies the tuberculosis pandemic involving 2 billion …

Protective immunity against Mycobacterium tuberculosis involves major histocompatibility
complex class I (MHC-I)-and CD1-restricted CD8 T cells, but the mechanisms underlying …

Mycobacterium tuberculosis and the closely related organism Mycobacterium bovis can
survive and replicate inside macrophages. Intracellular survival is at least in part attributed to …

Phagosomal biogenesis is a fundamental biological process of particular significance for the
function of phagocytic and antigen-presenting cells. The precise mechanisms governing …