Unconventional T cell targets for cancer immunotherapy
Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T
cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility …
cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility …
Targeting natural killer cells and natural killer T cells in cancer
Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo
Prophylactic vaccines for SARS-CoV-2 have lowered the incidence of severe COVID-19, but
emergence of viral variants that are antigenically distinct from the vaccine strains are of …
emergence of viral variants that are antigenically distinct from the vaccine strains are of …
The role of natural killer T cells in cancer—a phenotypical and functional approach
D Krijgsman, M Hokland, PJK Kuppen - Frontiers in immunology, 2018 - frontiersin.org
Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …
the innate and adaptive immune system. NKT cells can be subdivided into functional …
Natural killer T cells in cancer immunotherapy
S Nair, MV Dhodapkar - Frontiers in immunology, 2017 - frontiersin.org
Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …
Immune therapy for cancer
M Dougan, G Dranoff - Annual review of immunology, 2009 - annualreviews.org
Over the past decade, immune therapy has become a standard treatment for a variety of
cancers. Monoclonal antibodies, immune adjuvants, and vaccines against oncogenic …
cancers. Monoclonal antibodies, immune adjuvants, and vaccines against oncogenic …
Toward an understanding of NKT cell biology: progress and paradoxes
M Kronenberg - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique
properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an …
properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an …
MAIT cells: new guardians of the liver
A Kurioka, LJ Walker, P Klenerman… - Clinical & translational …, 2016 - Wiley Online Library
The liver is an important immunological organ that remains sterile and tolerogenic in
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …
Going both ways: immune regulation via CD1d-dependent NKT cells
DI Godfrey, M Kronenberg - The Journal of clinical …, 2004 - Am Soc Clin Investig
NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation
of immune responses associated with a broad range of diseases, including autoimmunity …
of immune responses associated with a broad range of diseases, including autoimmunity …
Cancer immunotherapy: a treatment for the masses
Cancer immunotherapy attempts to harness the exquisite power and specificity of the
immune system for the treatment of malignancy. Although cancer cells are less …
immune system for the treatment of malignancy. Although cancer cells are less …